ArticlePLoS computational biology2012
Macro-level modeling of the response of C. elegans reproduction to chronic heat stress.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Heat tolerance and genetic adaptations in Caenorhabditis briggsae: insights from comparative studies with Caenorhabditis elegans.Genetics · 2025Article
- Egg laying during stress-induced sleep ofmicroPublication biology · 2025Article
- Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.PLoS neglected tropical diseases · 2024Article
- Thermosensory behaviors of the free-living life stages ofbioRxiv : the preprint server for biology · 2024Article
- Natural variation in theeLife · 2024Article
- Serotonergic signaling plays a deeply conserved role in improving oocyte quality.Developmental biology · 2023Article
- High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans.PloS one · 2022Article
- Article
- Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans.BMC biology · 2021Article
- Dynamic Regulation of Adult-Specific Functions of the Nervous System by Signaling from the Reproductive System.Current biology : CB · 2019Article
- Neuropeptides encoded byPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton.Journal of visualized experiments : JoVE · 2018Article
- Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress.Physical review. E · 2017Article
- Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains.PLoS genetics · 2017Article
- Article
- Fitness Effects of Thermal Stress Differ Between Outcrossing and Selfing Populations inEvolutionary biology · 2017Article
- Sex Pheromones of C. elegans Males Prime the Female Reproductive System and Ameliorate the Effects of Heat Stress.PLoS genetics · 2015Article
- Specific microRNAs regulate heat stress responses in Caenorhabditis elegans.Scientific reports · 2015Article
- Experience Modulates the Reproductive Response to Heat Stress in C. elegans via Multiple Physiological Processes.PloS one · 2015Article
- Modulation of the maladaptive stress response to manage diseases of protein folding.PLoS biology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A major goal of systems biology is to understand how organism-level behavior arises from a myriad of molecular interactions. Often this involves complex sets of rules describing interactions among a large number of components. As an alternative, we have developed a simple, macro-level model to describe how chronic temperature stress affects reproduction in C. elegans. Our approach uses fundamental engineering principles, together with a limited set of experimentally derived facts, and provides quantitatively accurate predictions of performance under a range of physiologically relevant conditions. We generated detailed time-resolved experimental data to evaluate the ability of our model to describe the dynamics of C. elegans reproduction. We find considerable heterogeneity in responses of individual animals to heat stress, which can be understood as modulation of a few processes and may represent a strategy for coping with the ever-changing environment. Our experimental results and model provide quantitative insight into the breakdown of a robust biological system under stress and suggest, surprisingly, that the behavior of complex biological systems may be determined by a small number of key components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.