ArticleClinical ophthalmology (Auckland, N.Z.)2012
Staphylococcus aureus eye infections in two Indian hospitals: emergence of ST772 as a major clone.
Article in Clinical ophthalmology (Auckland, N.Z.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Genomic diversity and antimicrobial resistance ofMicrobial genomics · 2025Article
- Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis.Investigative ophthalmology & visual science · 2025Article
- Draft genome sequence of methicillin-resistantMicrobiology resource announcements · 2023Article
- Draft Genome Sequence of the Community-Associated Staphylococcus aureus Sequence Type 88 Strain LVP-7, Isolated from an Ocular Infection.Microbiology resource announcements · 2021Article
- Structural and biochemical characteristics of twoThe Journal of biological chemistry · 2020Article
- Article
- Antibiotic Susceptibility, Virulence Pattern, and Typing ofFrontiers in microbiology · 2019Article
- Molecular epidemiology and resistance profiles among healthcare- and community-associatedInfection and drug resistance · 2019Article
- Periorbital infections and conjunctivitis due to Panton-Valentine Leukocidin (PVL) positive Staphylococcus aureus in children.BMC infectious diseases · 2018Article
- Distribution of the Most PrevalentFrontiers in microbiology · 2018Review
- Emerging multidrug-resistant Bengal Bay clone ST772-MRSA-V in Norway: molecular epidemiology 2004-2014.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny.Scientific reports · 2017Article
- Article
- Characterization of Heterogeneous MRSA and MSSA with Reduced Susceptibility to Chlorhexidine in Kuwaiti Hospitals.Frontiers in microbiology · 2017Article
- Polymorphism in spa gene of Staphylococcus aureus from bovine subclinical mastitis.Veterinary world · 2016Article
- Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus.BMC genomics · 2015Article
- Dissemination of methicillin-resistant Staphylococcus aureus SCCmec type IV and SCCmec type V epidemic clones in a tertiary hospital: challenge to infection control.Epidemiology and infection · 2015Article
- Microbiota-driven immune cellular maturation is essential for antibody-mediated adaptive immunity to Staphylococcus aureus infection in the eye.Infection and immunity · 2014Article
- Screening and characterization of Staphylococcus aureus from ophthalmology clinic surfaces: a proposed surveillance tool.American journal of ophthalmology · 2014Article
- Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates.Genome announcements · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to perform molecular characterization of Staphylococcus aureus isolates causing a variety of eye infections from two major eye care hospitals in India.
methodsTwenty-four isolates from Aravind Eye Hospital, Madurai, India, and nine isolates from LV Prasad Eye Institute, Bhubaneswar, India, representing severe to nonsevere eye infections like microbial keratitis to lacrimal sac abscess, were characterized. Staphylococcal cassette chromosome mec typing, multilocus sequence typing, accessory gene regulator typing, staphylococcal protein A typing, and pulsed field gel electrophoresis were used, along with determination of the presence of Panton-Valentine leucocidin toxin and endotoxin gene cluster among each sequence type.
resultsThe majority of eye infections, both severe and nonsevere, were caused by sequence type (ST)772, positive for the Panton-Valentine leucocidin gene, and carrying methicillin-resistant staphylococcal cassette chromosome mec type V cassette (22/33, 67%). Some of the other sequence types that caused severe eye infections were ST1 (9%), 5 (3%), 72 (6%), 88 (3%), 121 (3%), and 672 (3%). This is the first report of the presence of ST1 and 88 in India.
conclusionAlthough the number of isolates included in this study was small, most of the eye infections were caused by community-associated S. aureus where patients had no history of hospitalization or treatment in the past year. In the case of six severe infections, patients were admitted for surgeries and there is probability of hospital infection. In addition, only methicillin-resistant S. aureus isolates carrying staphylococcal cassette chromosome mec type V were detected. Epidemic methicillin-resistant Staphylococcus aureus 15 (ST22) is a major ST found in health care as well as community settings in non-eye infections in India, but only one methicillin-sensitive S. aureus isolate belonging to ST22 was detected. Predominantly ST772, along with a few other STs, caused the 33 eye infections studied.
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