ArticleRNA (New York, N.Y.)2012
Widespread RNA 3'-end oligouridylation in mammals.
Article in RNA (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Application of Modified mRNA in Somatic Reprogramming to Pluripotency and Directed Conversion of Cell Fate.International journal of molecular sciences · 2021Review
- A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing.Nature reviews. Molecular cell biology · 2020Review
- Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.Nature structural & molecular biology · 2018Article
- The Nefarious Nexus of Noncoding RNAs in Cancer.International journal of molecular sciences · 2018Review
- Long Noncoding RNAs in the Pathogenesis of Barrett's Esophagus and Esophageal Carcinoma.Gastroenterology · 2017Review
- TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs.The EMBO journal · 2016Article
- RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs.Nucleic acids research · 2015Article
- Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.Nature communications · 2015Article
- A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1.Nucleic acids research · 2015Article
- Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life.BioMed research international · 2015Review
- Article
- SCOPE++: sequence classification of homoPolymer emissions.Genomics · 2014Article
- Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.Trends in genetics : TIG · 2014Review
- Detection of 3'-end RNA uridylation with a protein nanopore.ACS nano · 2014Article
- Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.RNA (New York, N.Y.) · 2013Article
- 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.BMC molecular biology · 2013Article
- The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.The EMBO journal · 2013Article
- Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants.Nucleic acids research · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Nontemplated 3'-end oligouridylation of RNA occurs in many species, including humans. Unlike the familiar phenomenon of polyadenylation, nontemplated addition of uridines to RNA is poorly characterized in higher eukaryotes. Recent studies have reported nontemplated 3'-end oligouridylation of small RNAs and mRNAs. Oligouridylation is involved in many aspects of microRNA biology from biogenesis to turnover of the mature species, and it may also mark long mRNAs for degradation by promoting decapping of the protective 5'-cap structure. To determine the prevalence of oligouridylation in higher eukaryotes, we used next-generation sequencing technology to deeply examine the population of small RNAs in human cells. Our data revealed widespread nontemplated nucleotide addition to the 3' ends of many classes of RNA, with short stretches of uridine being the most frequently added nucleotide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.