ArticleThe Journal of biological chemistry2012
Short chain dehydrogenase/reductase rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Enhanced Loss of Retinoic Acid Network Genes inCells · 2022Article
- Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly.Frontiers in cell and developmental biology · 2022Article
- Retinoids in Cutaneous Squamous Cell Carcinoma.Nutrients · 2021Review
- Dietary Vitamin A Impacts Refractory Telogen.Frontiers in cell and developmental biology · 2021Article
- Generation of Retinaldehyde for Retinoic Acid Biosynthesis.Biomolecules · 2019Review
- Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands.The Journal of biological chemistry · 2019Article
- Recent insights on the role and regulation of retinoic acid signaling during epicardial development.Genesis (New York, N.Y. : 2000) · 2019Review
- A 6-Gene Risk Signature Predicts Survival of Glioblastoma Multiforme.BioMed research international · 2019Article
- Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity.Scientific reports · 2018Article
- Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.Chemico-biological interactions · 2017Article
- The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-The Journal of biological chemistry · 2017Article
- Review
- Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate.Molecular biology and evolution · 2016Article
- Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties.Molecular and cellular biochemistry · 2016Article
- Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family.Chemico-biological interactions · 2015Article
- Mechanisms of retinoic acid signalling and its roles in organ and limb development.Nature reviews. Molecular cell biology · 2015Review
- Retinoid signaling in control of progenitor cell differentiation during mouse development.Seminars in cell & developmental biology · 2013Review
- Investigation of retinoic acid function during embryonic brain development using retinaldehyde-rescued Rdh10 knockout mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Enzymology of retinoic acid biosynthesis and degradation.Journal of lipid research · 2013Review
- The retinol dehydrogenase Rdh10 localizes to lipid droplets during acyl ester biosynthesis.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The enzymes responsible for the rate-limiting step in retinoic acid biosynthesis, the oxidation of retinol to retinaldehyde, during embryogenesis and in adulthood have not been fully defined. Here, we report that a novel member of the short chain dehydrogenase/reductase superfamily, frog sdr16c5, acts as a highly active retinol dehydrogenase (rdhe2) that promotes retinoic acid biosynthesis when expressed in mammalian cells. In vivo assays of rdhe2 function show that overexpression of rdhe2 in frog embryos leads to posteriorization and induction of defects resembling those caused by retinoic acid toxicity. Conversely, antisense morpholino-mediated knockdown of endogenous rdhe2 results in phenotypes consistent with retinoic acid deficiency, such as defects in anterior neural tube closure, microcephaly with small eye formation, disruption of somitogenesis, and curved body axis with bent tail. Higher doses of morpholino induce embryonic lethality. Analyses of retinoic acid levels using either endogenous retinoic acid-sensitive gene hoxd4 or retinoic acid reporter cell line both show that the levels of retinoic acid are significantly decreased in rdhe2 morphants. Taken together, these results provide strong evidence that Xenopus rdhe2 functions as a retinol dehydrogenase essential for frog embryonic development in vivo. Importantly, the retinol oxidizing activity of frog rdhe2 is conserved in its mouse homologs, suggesting that rdhe2-related enzymes may represent the previously unrecognized physiologically relevant retinol dehydrogenases that contribute to retinoic acid biosynthesis in higher vertebrates.
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