Evidence map›Paper›PMID 22290981›Full record

ArticleAntimicrobial agents and chemotherapy2012

In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.

Kerin L Tyrrell, Diane M Citron, Yumi A Warren, Ellie J C Goldstein

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. [Bacteremia by Actynomices oris].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Article
  8. Developments in Glycopeptide Antibiotics.ACS infectious diseases · 2018
    Article
  9. Actinomyces and related organisms in human infections.Clinical microbiology reviews · 2015
    Review
  10. Antibiotics and bacterial resistance in the 21st century.Perspectives in medicinal chemistry · 2014
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kerin L TyrrellR. M. Alden Research Lab, Culver City, California, USA. k.l.tyrrell@att.net
Diane M Citron
Yumi A Warren
Ellie J C Goldstein

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains of Corynebacterium species. Against nearly all Gram-positive strains, TD-1792 had an MIC₉₀ of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.

Indexed as

Anti-Bacterial AgentsBacteria, AnaerobicBacterial InfectionsCephalosporinsColony Count, MicrobialCorynebacteriumCulture MediaDaptomycinGlycopeptidesGram-Positive BacteriaHumansMicrobial Sensitivity TestsVancomycinAnti-Bacterial AgentscefilavancinCephalosporinsCulture MediaDaptomycinGlycopeptidesVancomycin

Identifiers

PMID22290981
PMCPMC3318369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.