Evidence map›Paper›PMID 22290975›Full record

ArticleAntimicrobial agents and chemotherapy2012

Small plasmids harboring qnrB19: a model for plasmid evolution mediated by site-specific recombination at oriT and Xer sites.

Tung Tran, Patricia Andres, Alejandro Petroni, Alfonso Soler-Bistué, Ezequiel Albornoz, Angeles Zorreguieta, Rodrigo Reyes-Lamothe, David J Sherratt, Alejandra Corso, Marcelo E Tolmasky

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. ChromosomalFrontiers in microbiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Functional Analysis of theAntibiotics (Basel, Switzerland) · 2020
    Article
  13. Article
  14. Carbapenemases: TransformingBiomolecules · 2020
    Review
  15. Article
  16. Article
  17. SmallFrontiers in microbiology · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tung TranCenter for Applied Biotechnology Studies, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA.
Patricia Andres
Alejandro Petroni
Alfonso Soler-Bistué
Ezequiel Albornoz
Angeles Zorreguieta
Rodrigo Reyes-Lamothe
David J Sherratt
Alejandra Corso
Marcelo E Tolmasky

Funding

Minority Health and Health Disparities International Research Training ProgramT37MD001368 · NIMHD · CALIFORNIA STATE UNIVERSITY FULLERTON · PI TOLMASKY, MARCELO E · 2005 to 2024
$3.9M
DEALING WITH ANTIBIOTIC RESISTANCE--ANTISENSE TECHNOLOGYR15AI047115 · NIAID · CALIFORNIA STATE UNIVERSITY FULLERTON · PI TOLMASKY, MARCELO E · 2000 to 2022
$1.8M
NIAID NIH HHS 2R15AI047115NIAID NIH HHS R15 AI047115NIMHD NIH HHS 2T37MD001368NIMHD NIH HHS T37 MD001368
6 · The paper itself

Abstract

Plasmids pPAB19-1, pPAB19-2, pPAB19-3, and pPAB19-4, isolated from Salmonella and Escherichia coli clinical strains from hospitals in Argentina, were completely sequenced. These plasmids include the qnrB19 gene and are 2,699, 3,082, 2,989, and 2,702 nucleotides long, respectively, and they share extensive homology among themselves and with other previously described small qnrB19-harboring plasmids. The genetic environment of qnrB19 in all four plasmids is identical to that in these other plasmids and in transposons such as Tn2012, Tn5387, and Tn5387-like. Nucleotide sequence comparisons among these and previously described plasmids showed a variable region characterized by being flanked by an oriT locus and a Xer recombination site. We propose that this arrangement could play a role in the evolution of plasmids and present a model for DNA swapping between plasmid molecules mediated by site-specific recombination events at oriT and a Xer target site.

Indexed as

ArgentinaBase SequenceBiological EvolutionDNA, BacterialEscherichia coliEscherichia coli InfectionsHumansMolecular Sequence DataPlasmidsPolymerase Chain ReactionRecombination, GeneticSalmonellaSalmonella InfectionsDNA, Bacterial

Identifiers

PMID22290975
PMCPMC3318318

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.