ArticleAntimicrobial agents and chemotherapy2012
Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed, 138 citations in OpenAlex.
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- Genomic Characterization of a Carbapenem-ResistantPathogens (Basel, Switzerland) · 2025Article
- Pan-genus analysis and typing of antimicrobial resistance plasmids in Acinetobacter.npj antimicrobials and resistance · 2025Article
- Characterization of the Diversity in Host Range of an Extensively Drug-Resistant (XDR) Type IV Secretion System-Encoding Plasmid inPathogens (Basel, Switzerland) · 2025Article
- Molecular epidemiology of carbapenem-resistantmSphere · 2025Article
- The Evolution of Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2025Review
- Analysis ofAntimicrobial agents and chemotherapy · 2024Article
- Examining the role of Acinetobacter baumannii plasmid types in disseminating antimicrobial resistance.npj antimicrobials and resistance · 2024Article
- A novel replication initiation region encoded in a widespread Acinetobacter plasmid lineage carrying a blaNDM-1 gene.PloS one · 2024Article
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- Detection and Typing of Plasmids in Acinetobacter baumannii UsingMicrobiology spectrum · 2023Article
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- Intra- and interpopulation transposition of mobile genetic elements driven by antibiotic selection.Nature ecology & evolution · 2022Article
- Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNature communications · 2022Article
- New Delhi Metallo-β-Lactamase-Producing Enterobacterales Bacteria, Switzerland, 2019-2020.Emerging infectious diseases · 2021Article
- First detection of a plasmid-encoded New-Delhi metallo-beta-lactamase-1 (NDM-1) producing Acinetobacter baumannii using whole genome sequencing, isolated in a clinical setting in Benin.Annals of clinical microbiology and antimicrobials · 2021Article
- Genotype-phenotype correlation of β-lactamase-producing uropathogenic Escherichia coli (UPEC) strains from Bangladesh.Scientific reports · 2020Article
- What do we know about plasmids carried by members of the Acinetobacter genus?World journal of microbiology & biotechnology · 2020Review
20 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spread of the bla(NDM-1) gene is gaining worldwide attentions. This gene is usually carried by large plasmids and has been discovered in diverse bacteria since it was originally found in Klebsiella pneumoniae. Here we report the complete sequences of a bla(NDM-1)-bearing plasmid, pNDM-BJ01, and its variant, pNDM-BJ02, isolated from clinical Acinetobacter lwoffii strains. The plasmid pNDM-BJ01 is 47.3 kb in size and cannot be classified into any known plasmid incompatibility group, thus representing a novel plasmid with an unknown maintenance mechanism. This plasmid contains both a bla(NDM-1) gene and a type IV secretion system (T4SS) gene cluster. The T4SS is assigned to the P-type T4SS group, which usually encode a short, rigid pilus, and the bla(NDM-1) gene is located within a composite transposon flanked by two insertion elements of ISAba125. Plasmid pNDM-BJ02 is nearly identical to pNDM-BJ01 except that one copy of the ISAba125 element is missing, and it is therefore regarded as a variant of pNDM-BJ01. Sequence alignment indicated that this bla(NDM-1)-containing composite transposon, which can also be captured by other mobile elements, was probably a product of multiple recombination events and can move as a whole by transposition.
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