ArticleAntimicrobial agents and chemotherapy2012
Evolutionary changes in antimicrobial resistance of invasive Neisseria meningitidis isolates in Belgium from 2000 to 2010: increasing prevalence of penicillin nonsusceptibility.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Meningococcal Antibiotic Resistance: Molecular Characterization of Isolates from Patients with Invasive Meningococcal Disease (IMD) in Greece.Antibiotics (Basel, Switzerland) · 2023Article
- Penicillin- and Ciprofloxacin-Resistant Invasive Neisseria meningitidis Isolates from Japan.Microbiology spectrum · 2022Article
- Antimicrobial Susceptibility Survey of Invasive Neisseria meningitidis, United States 2012-2016.The Journal of infectious diseases · 2022Article
- Acquisition of Ciprofloxacin Resistance Among an Expanding Clade of β-Lactamase-Positive, Serogroup Y Neisseria meningitidis in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Antibiotic susceptibility and molecular analysis of invasive Neisseria meningitidis recovered in the Republic of Ireland, 1996 to 2016.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Antibiotic resistance among invasive Neisseria meningitidis isolates in England, Wales and Northern Ireland (2010/11 to 2018/19).PloS one · 2021Article
- Epidemiological profile ofAccess microbiology · 2020Article
- Emergence and spread of resistant N. meningitidis implicated in invasive meningococcal diseases during the past decade (2008-2017).The Journal of antibiotics · 2019Review
- Neisseria meningitidis Antimicrobial Resistance in Italy, 2006 to 2016.Antimicrobial agents and chemotherapy · 2018Article
- Painful knees and hearing-loss: a rare presentation of meningococcal disease.BMJ case reports · 2016Article
- Population-Based Surveillance of Neisseria meningitidis Antimicrobial Resistance in the United States.Open forum infectious diseases · 2015Article
- Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis.Antimicrobial agents and chemotherapy · 2014Article
- Guidelines for the management of suspected and confirmed bacterial meningitis in Canadian children older than one month of age.Paediatrics & child health · 2014Article
- Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility.Antimicrobial agents and chemotherapy · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This study was conducted to evaluate the evolution of the antimicrobial susceptibility of Neisseria meningitidis causing invasive diseases in Belgium in the period of January 2000 to December 2010. A total of 1,933 cases of N. meningitidis from invasive infections were analyzed by antimicrobial susceptibility testing at the Belgian Meningococcal Reference Centre. The majority of strains were susceptible to antibiotics that are currently used for the treatment and prophylaxis of meningococcal disease, but the prevalence of clinical isolates with reduced susceptibility to penicillin increased over the years. The phenotyping, genotyping, and determination of MICs of penicillin G were performed. The systematic shift of the curves toward higher penicillin MICs in the susceptible population indicated that this population became less sensitive to penicillin in this period. A 402-bp DNA fragment in the 3' end of penA was sequenced for the 296 nonsusceptible meningococcal strains isolated between 2000 and 2010 to examine the genetic diversity and evolution of their penA gene. In conclusion, the data obtained in our study support the statement that the position of penicillin G as a first choice in the treatment of invasive meningococcal diseases in Belgium should be reexamined. Despite an important number of isolates displaying a reduced susceptibility to penicillin, at present the expanded-spectrum cephalosporins, such as ceftriaxone, are not affected. The follow-up of the evolutionary changes in antimicrobial resistance has also proved to be essential for the recommendation of an appropriate antimicrobial treatment for invasive meningococcal diseases.
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