ArticlePediatric pulmonology2012
Maternal smoking during pregnancy, prematurity and recurrent wheezing in early childhood.
Article in Pediatric pulmonology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Tobacco Smoking During Pregnancy Is Associated With Increased Risk of Moderate/Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years.BMJ open · 2014Pooled it
- Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Maternal Black Race and Persistent Wheezing Illness in Former Extremely Low Gestational Age Newborns: Secondary Analysis of a Randomized Trial.The Journal of pediatrics · 2018Trial
- Chronic respiratory morbidity and wheeze after preterm birth: a narrative review.Frontiers in pediatrics · 2026Review
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Understanding the burden of food allergy among urban and rural school children from north India.The World Allergy Organization journal · 2024Article
- Prevalence and Risk Factors of Childhood Asthma in Jazan Region, Saudi Arabia.Journal of asthma and allergy · 2024Article
- Prematurity-associated wheeze: current knowledge and opportunities for further investigation.Pediatric research · 2023Review
- Article
- Prevalence and influencing factors of wheeze and asthma among preschool children in Urumqi city: a cross-sectional survey.Scientific reports · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Prenatal and perinatal risk factors of food allergy in Taiwanese young children.The World Allergy Organization journal · 2022Article
- Article
- Predicting Lung Health Trajectories for Survivors of Preterm Birth.Frontiers in pediatrics · 2020Review
- Risk factors for chronic lung disease and asthma differ among children born extremely preterm.Pediatric pulmonology · 2018Article
- Exhaled biomarkers in childhood asthma: old and new approaches.Asthma research and practice · 2018Review
- Maternal smoking in pregnancy and its influence on childhood asthma.ERJ open research · 2016Review
- Preterm Birth with Childhood Asthma: The Role of Degree of Prematurity and Asthma Definitions.American journal of respiratory and critical care medicine · 2015Article
- Environmental Pollution and the Developing Lung.Clinical pulmonary medicine · 2015Article
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11 authors at 1 institution in 1 country.
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Abstract
backgroundPrenatal maternal smoking and prematurity independently affect wheezing and asthma in childhood.
objectiveWe sought to evaluate the interactive effects of maternal smoking and prematurity upon the development of early childhood wheezing.
methodsWe evaluated 1,448 children with smoke exposure data from a prospective urban birth cohort in Boston. Maternal antenatal and postnatal exposure was determined from standardized questionnaires. Gestational age was assessed by the first day of the last menstrual period and early prenatal ultrasound (preterm < 37 weeks gestation). Wheezing episodes were determined from medical record extraction of well and ill/unscheduled visits. The primary outcome was recurrent wheezing, defined as ≥ 4 episodes of physician documented wheezing. Logistic regression models and zero inflated negative binomial regression (for number of episodes of wheeze) assessed the independent and joint association of prematurity and maternal antenatal smoking on recurrent wheeze, controlling for relevant covariates.
resultsIn the cohort, 90 (6%) children had recurrent wheezing, 147 (10%) were exposed to in utero maternal smoke and 419 (29%) were premature. Prematurity (odds ratio [OR] 2.0; 95% confidence interval [CI], 1.3-3.1) was associated with an increased risk of recurrent wheezing, but in utero maternal smoking was not (OR 1.1, 95% CI 0.5-2.4). Jointly, maternal smoke exposure and prematurity caused an increased risk of recurrent wheezing (OR 3.8, 95% CI 1.8-8.0). There was an interaction between prematurity and maternal smoking upon episodes of wheezing (P = 0.049).
conclusionsWe demonstrated an interaction between maternal smoking during pregnancy and prematurity on childhood wheezing in this urban, multiethnic birth cohort.
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