ReviewNature reviews. Genetics2012
Understanding transgenerational epigenetic inheritance via the gametes in mammals.
Review in Nature reviews. Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
305 citing papers in PubMed.
- Influence of intergenerationalFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Trial
- Partial Reproducibility and Pleiotropic Epigenetic QTLs inPlants (Basel, Switzerland) · 2026Article
- Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.Plant biology (Stuttgart, Germany) · 2026Article
- Transgenerational Epigenetic Effect of Cryopreservation of F0 Rooster Sperm (Animals : an open access journal from MDPI · 2026Article
- Germline and Embryonic Mechanisms in the Epigenetic Inheritance of Neurodevelopmental and Cognitive Traits in Mammals.Biomolecules · 2026Review
- Paternal Microplastic Exposure Alters Sperm Small Noncoding RNAs and Affects Offspring Metabolic Health in Mice.Journal of the Endocrine Society · 2026Article
- Population epigenetics: Historical notes and applications in human health.Genetics and molecular biology · 2026Article
- Molecular Tools for Non-invasive Sexing of Wildlife.Advances in experimental medicine and biology · 2026Review
- Association of social determinants of health and cardiovascular complications in type 2 diabetes in Colombia.World journal of diabetes · 2025Article
- Review
- Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep.International journal of molecular sciences · 2025Article
- Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025Review
- Understanding and applying gene-environment interactions: a guide for nutrition professionals with an emphasis on integration in African research settings.Nutrition reviews · 2025Review
- Epigenetic variation in light of population genetic practice.Nature communications · 2025Review
- Adaptive Significance of Non-coding RNAs: Insights from Cancer Biology.Molecular biology and evolution · 2025Review
- Human culture is uniquely open-ended rather than uniquely cumulative.Nature human behaviour · 2025Review
- In Vıtro Productıon of Bovıne Blastocysts and Cryopreservatıon Technıques.Advances in experimental medicine and biology · 2025Review
- Transgenerational inheritance of hepatic steatosis in mice: sperm methylome is largely reprogrammed and inherited but does not globally influence liver transcriptome.Environmental epigenetics · 2025Article
- Associations between a paternal healthy lifestyle score and its individual components with childhood overweight and obesity.Andrology · 2025Article
- Observational methods for human studies of transgenerational effects.Epigenetics · 2024Article
245 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that information that is not contained in the DNA sequence - epigenetic information - can be inherited from the parent to the offspring. However, many questions remain unanswered regarding the extent and mechanisms of such inheritance. In this Review, we consider the evidence for transgenerational epigenetic inheritance via the gametes, including cases of environmentally induced epigenetic changes. The molecular basis of this inheritance remains unclear, but recent evidence points towards diffusible factors, in particular RNA, rather than DNA methylation or chromatin. Interestingly, many cases of epigenetic inheritance seem to involve repeat sequences.
Indexed as
Identifiers
22290458What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.