ArticleParasitology research2012
Allergic dermatitis by Dirofilaria repens in a dog: clinical picture and treatment.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Field clinical study evaluating the efficacy and safety of an oral formulation containing milbemycin oxime/praziquantel (Milbemax®, Novartis Animal Health) in the chemoprevention of the zoonotic canine infection by Dirofilaria repens.Parasites & vectors · 2014Trial
- Potential efficacy of monthly administrations of spot-on moxidectin 2.5%/imidacloprid 10% in the simultaneous prevention of major canine filarioses.Parasitology research · 2013Trial
- A Rare Case Report of a HumanMicroorganisms · 2025Article
- A Rare Case of Dirofilariasis in the Genian Region.Diagnostics (Basel, Switzerland) · 2024Article
- Subcutaneous dirofilariasis due to Dirofilaria immitis in a dog in Brazil: first report.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2023Article
- Cutaneous filarioid nematodes of dogs in the United States: Are they emerging, neglected, or underdiagnosed parasites?Frontiers in veterinary science · 2023Review
- Review
- Usual or unusual presentations of Dirofilaria repens in two sibling dogs: a case report.Parasitology research · 2021Article
- Current trends in canine dirofilariosis in Austria-do we face a pre-endemic status?Parasitology research · 2020Article
- Recent advances on Dirofilaria repens in dogs and humans in Europe.Parasites & vectors · 2018Review
- Subcutaneous dirofilariosis (Dirofilaria repens): an infection spreading throughout the old world.Parasites & vectors · 2017Review
- Subcutaneous Dirofilaria repens infestation in non-descript canines.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Adult of Dirofilaria repens in a dog with recurrent multiple subcutaneous nodular lesions.Parasitology research · 2014Article
- Dirofilaria repens infection in a dog imported to Norway.Acta veterinaria Scandinavica · 2014Article
- Microfilarial periodicity of Dirofilaria repens in naturally infested dogs.Parasitology research · 2013Article
- Dirofilaria repens microfilariae in Aedes vexans mosquitoes in Slovakia.Parasitology research · 2013Article
- Qualitative risk assessment for the endemisation of Dirofilaria repens in the state of Brandenburg (Germany) based on temperature-dependent vector competence.Parasitology research · 2013Article
- Evidences of increasing risk of dirofilarioses in southern Italy.Parasitology research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult stages of Dirofilaria repens (Nematoda, Filarioidea) reside in the subcutaneous tissues of the definitive or occasional host as dogs, other animals, and humans, and it is transmitted by mosquitoes. Canine infections with adults and circulating larvae of D. repens are often considered asymptomatic, although in some cases, the parasite causes subcutaneous nodules, diffused dermatitis, skin lesions, and itching. This report provides a complete clinical description of an unusual case of allergic diffused dermatitis caused by D. repens in a naturally infected dog and its successful treatment with the use of a spot-on solution containing imidacloprid 10%/moxidectin 2.5%. The dog presented multiple pustules and alopecic areas with lichenification, hyperpigmentation, and erythematous scaling margins without pruritus. Histological examination was compatible with allergic dermatitis. After being unsuccessfully managed for suspected food hypersensitivity, with a significantly worsening of the lesions, a Knott’s analysis detected nematode larvae in the blood. Morphological and molecular identification showed them to be D. repens. The dog was then treated with a single administration of a spot-on formulation containing imidacloprid 10%/moxidectin 2.5%, and the dermatological signs completely resolved within 2 months after treatment. The dog showed no recurrence of the lesions, and no circulating microfilariae were found upon microscopic and molecular examination for six consecutive months after treatment. This report indicates the apparent primary role of D. repens in causing hypersensitivity-like skin disease without pruritus in a dog. It also confirms, as recently shown elsewhere, the efficacy of imidacloprid 10%/moxidectin 2.5% in the treatment of dermatitis caused by D. repens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.