ArticleStem cell reviews and reports2012
Ontogeny and Homeostasis of Adult Epithelial Skin Stem Cells.
Article in Stem cell reviews and reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.The EMBO journal · 2023Article
- Notch Signaling Pathway Expression in the Skin of Leprosy Patients: Association With Skin and Neural Damage.Frontiers in immunology · 2020Observational
- Article
- Epigenetic control in skin development, homeostasis and injury repair.Experimental dermatology · 2019Review
- Overexpression of epigen during embryonic development induces reversible, epidermal growth factor receptor-dependent sebaceous gland hyperplasia.Molecular and cellular biology · 2014Article
- Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.International review of cell and molecular biology · 2013Review
- Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer.The EMBO journal · 2012Article
- Hairy tale of signaling in hair follicle development and cycling.Seminars in cell & developmental biology · 2012Review
- The ontogeny of somatic stem cells.Stem cell reviews and reports · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Mouse epithelial skin stem cells constitute an important model system for understanding the dynamics of stem cell emergence and behavior in an intact vertebrate tissue. Recent published work defined discrete populations of epithelial stem cells in the adult skin epithelium, which reside in the hair follicle bulge and germ, isthmus, sebaceous gland and inter-follicular epidermis. Adult epidermal and hair follicle stem cells seem to adopt mostly symmetric or unidirectional fate decisions of either one of two possible fates: (1) differentiate and be lost from the tissue or (2) expand symmetrically to self-renew. Asymmetric divisions appear to be mostly implicated in differentiation and stratification of the epidermis. While mechanisms of adult stem cell homeostasis begin to be unraveled, the embryonic origin of the adult epithelial skin stem cells is poorly understood. Recent studies reported Sox9, Lgr6, and Runx1 expression in subpopulations of cells in the embryonic hair placode. These subpopulations seem to act as precursors of different classes of adult epithelial stem cells. In particular, Runx1 regulates a Wnt-mediated cross-talk between the nascent adult-type hair follicle stem cells and their environment, which is essential for timely stem cell emergence, proper maturation, long-term differentiation potential, and maintenance. The new data begin to define the basic dynamics and regulatory pathways governing the ontogeny of adult epithelial stem cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.