SynthesisSchizophrenia bulletin2013
Content and quality of 10,000 controlled trials in schizophrenia over 60 years.
Synthesis in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Outcomes in intervention research on snakebite envenomation: a systematic review.F1000Research · 2022Pooled it
- Pooled it
- Music therapy for people with schizophrenia and schizophrenia-like disorders.The Cochrane database of systematic reviews · 2017Pooled it
- Bifeprunox versus placebo for schizophrenia.The Cochrane database of systematic reviews · 2016Pooled it
- Choosing important health outcomes for comparative effectiveness research: a systematic review.PloS one · 2014Pooled it
- Trial
- HMG-CoA reductase inhibitors (statins) versus placebo for people with schizophrenia.The Cochrane database of systematic reviews · 2025Article
- In Pursuit of Recovery: A Comparative Study of Stakeholder Perspectives on Outcomes of People with Psychosis.Community mental health journal · 2025Article
- Are the results of open randomised controlled trials comparing antipsychotic drugs in schizophrenia biased? Exploratory meta- and subgroup analysis.Schizophrenia (Heidelberg, Germany) · 2024Article
- A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study.The Lancet. Respiratory medicine · 2022Review
- A pilot study assessing the similarity between core outcome sets and outcomes included in health technology assessments.F1000Research · 2021Article
- Acute interventions for aggression and agitation in psychosis: study protocol for a systematic review and network meta-analysis.BMJ open · 2019Article
- Outcome Selection and Methodological Quality of Major and Minor Shoulder Surgery Studies: A Scoping Review.Clinical orthopaedics and related research · 2019Article
- The evidence-based group-level symptom-reduction model as the organizing principle for mental health care: time for change?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- A systematic scoping review of psychological therapies for psychosis within acute psychiatric in-patient settings.The British journal of psychiatry : the journal of mental science · 2018Article
- The COMET Handbook: version 1.0.Trials · 2017Review
- Improving core outcome set development: qualitative interviews with developers provided pointers to inform guidance.Journal of clinical epidemiology · 2017Article
- Article
- Improving the relevance and consistency of outcomes in comparative effectiveness research.Journal of comparative effectiveness research · 2016Review
- Schizophrenia trials conducted in African countries: a drop of evidence in the ocean of morbidity?International journal of mental health systems · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveTo carry out an up-to-date comprehensive survey of the content and quality of intervention trials relevant to the treatment of people with schizophrenia.
designData were extracted and analyzed from 10,000 trials on the Cochrane Schizophrenia Group's Register.
main outcome measuresSource, type and date of publication, country of origin, language, size of trial, interventions, and outcome measures.
resultsIn the last decade, there has been a great increase in the number of trials relevant to schizophrenia and an improvement in the accessibility to reports. The number of trials per year is rising (currently ∼600/year) with China now producing 25% of the annual total. The number of reports of trials is increasing at an even greater rate due to multiple publications. Drug trials still dominate (83%) although an increasing proportion of studies are now evaluating psychological therapies (21%). Trials remain small (median 60 people) and often employ new nonvalidated outcomes scales (2194 different scales were employed with every fifth trial introducing a new rating instrument).
conclusionsA more collaborative, pragmatic, and patient-centered approach is necessary to produce larger schizophrenia trials. Wider consultation and careful consideration of all relevant perspectives would result in trials with greater clinical utility and direct value to people with the illness and their families or carers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.