Evidence map›Paper›PMID 22290243›Full record

ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012

Frailty and sarcopenia: definitions and outcome parameters.

C Cooper, W Dere, W Evans, J A Kanis, R Rizzoli, A A Sayer, C C Sieber, J-M Kaufman, G Abellan van Kan, S Boonen and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Sleep and frailty risk: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2020
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  6. Systematic review and meta-analysis of prevalence of sarcopenia in post acute inpatient rehabilitation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

C CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, England, UK. cc@mrc.soton.ac.uk
W Dere
W Evans
J A Kanis
R Rizzoli
A A Sayer
C C Sieber
J-M Kaufman
G Abellan van Kan
S Boonen
J Adachi
B Mitlak
Y Tsouderos
Y Rolland
J-Y L Reginster

Funding

Medical Research Council MC_U147585824Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015
6 · The paper itself

Abstract

An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.

Indexed as

Frail ElderlyAgedHumansOsteoporosisSarcopenia

Identifiers

PMID22290243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.