ArticleBrain research2012
Auditory cortex lesions do not disrupt habituation of HPA axis responses to repeated noise stress.
Article in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Auditory steady state responses elicited by silent gaps embedded within a broadband noise.BMC neuroscience · 2022Article
- A genetically identified population of layer 4 neurons in auditory cortex that contributes to pre-pulse inhibition of the acoustic startle response.Frontiers in neural circuits · 2022Article
- Amyloid Pathology in the Central Auditory Pathway of 5XFAD Mice Appears First in Auditory Cortex.Journal of Alzheimer's disease : JAD · 2022Article
- Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress.Frontiers in integrative neuroscience · 2022Review
- A Cortico-Collicular Amplification Mechanism for Gap Detection.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Endocannabinoid signaling as an intrinsic component of the circuits mediating adaptive responses to repeated stress exposure in adult male sprague dawley rats.Stress (Amsterdam, Netherlands) · 2020Article
- Remote CB1 receptor antagonist administration reveals multiple sites of tonic and phasic endocannabinoid neuroendocrine regulation.Psychoneuroendocrinology · 2020Article
- A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response.Frontiers in neural circuits · 2020Article
- Primary auditory cortex regulates threat memory specificity.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Evidence for the Integration of Stress-Related Signals by the Rostral Posterior Hypothalamic Nucleus in the Regulation of Acute and Repeated Stress-Evoked Hypothalamo-Pituitary-Adrenal Response in Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders.Neuroscience and biobehavioral reviews · 2015Review
- Melatonin Attenuates Noise Stress-induced Gastrointestinal Motility Disorder and Gastric Stress Ulcer: Role of Gastrointestinal Hormones and Oxidative Stress in Rats.Journal of neurogastroenterology and motility · 2015Article
- Habituation of hypothalamic-pituitary-adrenocortical axis hormones to repeated homotypic stress and subsequent heterotypic stressor exposure in male and female rats.Stress (Amsterdam, Netherlands) · 2014Article
- Stressor-specific effects of sex on HPA axis hormones and activation of stress-related neurocircuitry.Stress (Amsterdam, Netherlands) · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
Previous research has suggested that sensory areas may play a role in adaptation to repeated stress. The auditory cortex was the target of the present studies because it is a major projection area of the auditory thalamus, where functional inactivation disrupts stress habituation to repeated loud noise. Large bilateral excitotoxic lesions of the auditory cortex were made in male rats 2 weeks prior to (Experiment 1) or a few days after (Experiment 2) a 5 day 30 min repeated 95 dBA noise or no noise regimen. Blood was collected immediately after exposure on days 1, 3, and 5. Two weeks after the 5th exposure, the rats were retested with 30 min noise or no noise to determine retention of the habituated responses. Animals were killed immediately after the retest and trunk blood and brains collected for lesion verification. Plasma adrenocorticotropic hormone (ACTH) and corticosterone levels were determined. In both experiments, significant between-subjects effects were found for noise (95 dBA or no noise) but not for surgery (lesion, sham, or no surgery control rats), with lesion groups exhibiting similar levels of ACTH and corticosterone across days as the sham and no surgery control groups. All noise exposed groups displayed similar habituation rates and retention levels. A third experiment indicated that similar auditory cortex lesions significantly disrupted background noise gap detection in an acoustic startle paradigm. Overall, these data suggest that the information mediating hypothalamic-pituitary-adrenal axis response habituation to repeated loud noise exposures is not derived from the auditory cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.