ArticleCellular and molecular neurobiology2012
Stress and the Stomach: Corticotropin-Releasing Factor May Protect the Gastric Mucosa in Stress Through Involvement of Glucocorticoids.
Article in Cellular and molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 22 citations in OpenAlex.
- Non-Invasive Remote Ischemic Preconditioning May Protect the Gastric Mucosa Against Ischemia-Reperfusion-Induced Injury Through Involvement of Glucocorticoids.Frontiers in pharmacology · 2021Article
- The peripheral corticotropin-releasing factor (CRF)-induced analgesic effect on somatic pain sensitivity in conscious rats: involving CRF, opioid and glucocorticoid receptors.Inflammopharmacology · 2018Review
- The Realization of the Brain-Gut Interactions with Corticotropin-Releasing Factor and Glucocorticoids.Current neuropharmacology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress may contribute to the development of gastric ulcer disease. The results of our previous investigations suggest that glucocorticoids released during acute stress act as gastroprotective hormones, and not as ulcerogenic agents as has been generally accepted for a long time. In this study, we investigated whether corticotropin-releasing factor (CRF) may protect the gastric mucosa against stress-induced gastric injury through involvement of glucocorticoids. Intraperitoneal administration of CRF (1.25 μg/kg, 30 min before stress) markedly increased plasma corticosterone level (at 15 and 30 min after the administration) and significantly suppressed the occurrence of gastric erosion induced by 3-h cold-restraint stress (at 10°C) in conscious rats. To test the participation of corticosterone in the gastroprotective effect of exogenous CRF, two approaches were used: pretreatment by the inhibitor of glucocorticoid synthesis, metyrapone (30 mg/kg, i.p.) and the antagonist of glucocorticoid receptors RU-38486 (20 mg/kg, i.p.). Metyrapone injected shortly before CRF administration caused a fast inhibition of CRF-induced corticosterone response and reversed the protective effect of CRF on the gastric mucosa against the stress-induced erosion. The gastroprotective effect of CRF was also attenuated by the pretreatment rats with glucocorticoid receptor antagonist RU-38486. The results suggest that exogenous CRF may protect the gastric mucosa against stress-induced gastric injury through involvement of glucocorticoids.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.