ArticleInfection and immunity2012
Microevolution in fimH gene of mucosa-associated Escherichia coli strains isolated from pediatric patients with inflammatory bowel disease.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
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- Short-sighted evolution of virulence for invasive gut microbes: From hypothesis to tests.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Type 1 fimbrial phase variation in multidrug-resistant asymptomatic uropathogenic Escherichia coli clinical isolates upon adherence to HTB-4 cells.Folia microbiologica · 2024Article
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- Characterization of Adherent-InvasiveInternational journal of molecular sciences · 2022Article
- Adhesion of Enteropathogenic, Enterotoxigenic, and Commensal Escherichia coli to the Major Zymogen Granule Membrane Glycoprotein 2.Applied and environmental microbiology · 2022Article
- Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent-InvasiveFrontiers in cellular and infection microbiology · 2022Article
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- Characterization of mucosa-associated Escherichia coli strains isolated from Crohn's disease patients in Brazil.BMC microbiology · 2020Article
- Why the discovery of adherent-invasiveWorld journal of biological chemistry · 2020Review
- The role of major virulence factors and pathogenicity of adherent-invasivePrzeglad gastroenterologiczny · 2020Review
- Growth Control of Adherent-InvasiveMicroorganisms · 2019Article
- Lactoferrin in Aseptic and Septic Inflammation.Molecules (Basel, Switzerland) · 2019Review
- Genetic and Phenotypic Features to Screen for Putative Adherent-InvasiveFrontiers in microbiology · 2019Article
- Amino Acid Substitutions and Differential Gene Expression of Outer Membrane Proteins in Adherent-InvasiveFrontiers in microbiology · 2019Article
- Comparative genomics reveals new single-nucleotide polymorphisms that can assist in identification of adherent-invasive Escherichia coli.Scientific reports · 2018Article
- Investigation of adherent-invasiveMedical journal of the Islamic Republic of Iran · 2018Article
- Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.Immunological reviews · 2017Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies reported increased numbers of mucosa-associated Escherichia coli strains in patients with inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC). The majority of E. coli strains possess type 1 fimbriae, whose tip fibrillum protein, FimH, naturally undergoes amino acid replacements, an important process in the adaptation of commensal E. coli strains to environmental changes, like those observed in IBD and urinary tract infections. In this study, we analyzed mutational patterns in the fimH gene of 52 mucosa-associated E. coli strains isolated from IBD and non-IBD pediatric patients, in order to investigate microevolution of this genetic trait. FimH-positive strains were also phylogenetically typed and tested for their adhesive ability on Caco-2 cells. Specific FimH alleles for each grouping feature were found. Mutations G66S and V27A were related to CD, while mutations A242V, V163A, and T74I were attributed to UC. Otherwise, the G66S, N70S, and S78N mutations were specifically attributed to B2/D phylogroups. The N70S and A119V mutations were related to adhesive E. coli strains. Phylogroup B2, adhesive, and IBD E. coli strains showed a higher site substitution rate (SSR) in the fimH gene, together with a higher number of mutations. The degree of naïve mucosal inflammation was related to specific FimH alleles. Moreover, we could suggest that the V27A mutation is pathoadaptive for the CD intestinal habitat, while we could also suggest that both the N70S and S78N mutations are related to the more virulent E. coli B2 phylogroup. In conclusion, we found some FimH variants that seem to be more involved than others in the evolution of IBD pathogenesis.
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