Evidence map›Paper›PMID 22289720›Full record

ReviewCancer letters2014

Epigenetic biomarkers in skin cancer.

Edward S Greenberg, Kelly K Chong, Kelly T Huynh, Ryo Tanaka, Dave S B Hoon

Abstract readReview
In one paragraph

Review in Cancer letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Phytochemicals as Immunomodulatory Agents in Melanoma.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Edward S GreenbergDepartment of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.
Kelly K Chong
Kelly T Huynh
Ryo Tanaka
Dave S B Hoon

Funding

SURGICAL ONCOLOGY WITH COMBINATION THERMO-CHEMOTHERAPYP01CA029605 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COCHRAN, ALISTAIR JOHN · 1985 to 2013
$75.2M
TUMOR ANTIGENS THAT ELICIT HUMORAL IMMUNE RESPONSES IN CANCER PATIENTSP01CA012582 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORTON, DONALD L · 1985 to 2010
$40.8M
NCI NIH HHS P01 CA012582NCI NIH HHS P01 CA029605
6 · The paper itself

Abstract

Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in tissue and in blood as circulating DNA in melanoma patients. There is strong evidence that biomarkers in cutaneous melanoma will have an important role as companions to therapeutics and overall patient management. Important progress has been made in epigenetic melanoma biomarker development and verification of clinical utility, and this review discusses some of the key current developments and existing challenges.

Indexed as

Epigenesis, GeneticAnimalsBiomarkers, TumorDNA MethylationGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenetic TestingHistonesHumansMelanomaMicroRNAsPhenotypePredictive Value of TestsPrognosisSkin NeoplasmsBiomarkers, TumorHistonesMicroRNAsbasal cell carcinomaBCBCCbiochemotherapybiomarkerBiomarkerBMCAEcapillary array electrophoresiscell-free circulating nucleic acidcf-CNAChIPchromatin immunoprecipitationCIMPcirculating tumor cellCoBRAcombined bisulfite restriction analysisCpG island methylator phenotypeCTCCTCLcutaneous T-cell lymphomaDNA methyltransferaseDNMTEpigeneticsIHCimmunohistochemistryLINE-1long interspersed nuclear element-1MCCMelanomamerkel cell carcinomamethylated-in-tumorMethylationmethylation-specific realtime PCRMicroRNAmicro-RNAsMINTmiRNAMSPOSoverall survivalPCRpolymerase chain reactionPrognosisreceiver operating characteristicsROCSBMSCCsodium bisulfite modificationsquamous cell carcinomatemozolomideTMZTRGtumor-related genesuntranslated regionUTR

Identifiers

PMID22289720
PMCPMC3391356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.