Evidence map›Paper›PMID 22289413›Full record

ArticleEarly human development2012

The development of the circadian heart rate rhythm (CHR) in Asian infants.

Toke Hoppenbrouwers, Flavia Oliveira, Stanislaus Sandarupa, Michael Khoo, Michael Neuman, Rangasamy Ramanathan

Abstract read
In one paragraph

Article in Early human development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Toke HoppenbrouwersUniversity of Southern California Division of Neonatal Medicine, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA. hoppenbrou@earthlink.net
Flavia Oliveira
Stanislaus Sandarupa
Michael Khoo
Michael Neuman
Rangasamy Ramanathan
LAC+USC Medical Center · USViterbo University · USMichigan Technological University · USMichigan United · US

Funding

TrainingP41EB001978 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI D'ARGENIO, DAVID Z · 2003 to 2017
$18.1M
WORKSHOPP41RR001861 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RODMAN, JOHN H. · 1985 to 2002
$3.2M
NCRR NIH HHS P41 RR001861NIBIB NIH HHS P41 EB001978
6 · The paper itself

Abstract

objectiveTo test the hypothesis that term-born Asian infants, at reduced risk to die of Sudden Infant Death Syndrome (SIDS) exhibit a circadian heart rate rhythm (CHR) at a later age than non-Asian term infants.

methodRepeated overnight heart rate (HR) traces obtained with a battery-operated Polar S810i heart-rate monitor at home in 17 Asian Torajan infants in Indonesia, were compared with those of 52 non-Asian infants monitored as part of the Collaborative Home Infant Monitoring Evaluation (CHIME). HR was determined using a moving window averaging technique. A comparison of median HR during quiet sleep (QS) episodes (identified by minimum HR variability), established the presence of CHR.

resultsSeventy three percent of non-Asian CHIME infants ≤7 weeks exhibited CHR compared to 45% of Asian Torajan infants. Between 8 and 12 weeks, 94% of non-Asian CHIME infants exhibited CHR, compared to 33% of Asian Torajan infants (p<0.001). Forty seven and 56% of Asian Torajan infants exhibited the CHR at the age intervals of 16-20 weeks and 21-25 weeks respectively. Active wakefulness percentages as a function of the entire recording and median QS HR were not significantly different in the two groups.

conclusionDespite the fact that Asian Torajan infants were on average a week older than non-Asian CHIME babies, between two and three months of age only one in three exhibited the CHR, compared to virtually all non-Asian CHIME infants. We speculate that the cause of this difference rests in the infants' environment rather than their genetic origin.

Indexed as

Age FactorsAsian PeopleChild DevelopmentCircadian RhythmFemaleHeart RateHumansIndonesiaInfantInfant, NewbornMaleMonitoring, PhysiologicPolysomnographySudden Infant Death

Identifiers

PMID22289413
PMCPMC4490788
OpenAlexW2038756998

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.