Evidence map›Paper›PMID 22289280›Full record

Trial reportBMC complementary and alternative medicine2012

Impact of Tai Chi exercise on multiple fracture-related risk factors in post-menopausal osteopenic women: a pilot pragmatic, randomized trial.

Peter M Wayne, Douglas P Kiel, Julie E Buring, Ellen M Connors, Paolo Bonato, Gloria Y Yeh, Calvin J Cohen, Chiara Mancinelli, Roger B Davis

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 20 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01039012 phase2unknown statusnot on this map

Tai Chi for Osteopenic Women: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorHarvard University Faculty of MedicineRan2008 to 2010Enrolled86ConditionsOsteopeniaArmsTai Chi, Standard Care
NCT04019301 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Caring for Caregivers With Mind-body Exercise

TypeinterventionalSponsorUniversity of HoustonRan2019 to 2022Enrolled47ConditionsCaregiver Distress, Physical Function, Quality of LifeArmsBaduanjin Qigong, Community-based, Baduanjin Qigong, Internet-based
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 20 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Comparative efficacy of different traditional Chinese exercises on bone mineral density in older adults: a systematic review and network meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  2. The impact of Tai Chi on osteoporosis and osteopenia in middle-aged and elderly adults: a systematic review and meta-analysis of randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  8. Efficacy and safety of tai chi exercise on bone health: An umbrella review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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  13. Exercise to improve functional outcomes in persons with osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
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  15. Health benefits of tai chi: What is the evidence?Canadian family physician Medecin de famille canadien · 2016
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  16. Effects of tai chi exercise on bone health in perimenopausal and postmenopausal women: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Peter M WayneHarvard Medical School, Boston, MA, USA. pwayne@partners.org
Douglas P Kiel
Julie E Buring
Ellen M Connors
Paolo Bonato
Gloria Y Yeh
Calvin J Cohen
Chiara Mancinelli
Roger B Davis
Harvard University · USHarvard Vanguard Medical Associates · USBeth Israel Deaconess Medical Center · USHebrew SeniorLife · USSpaulding Rehabilitation Hospital · US

Funding

NESA Acupuncture Research CollaborativeU19AT002022 · NCCIH · NEW ENGLAND SCHOOL OF ACUPUNCTURE · PI WAYNE, PETER MICHAEL · 2003 to 2009
$4.0M
Tai Chi for Osteopenic Women: A Pilot Randomized Controlled TrialR21AT003503 · NCCIH · HARVARD MEDICAL SCHOOL · PI WAYNE, PETER MICHAEL · 2006 to 2009
$808k
NCCIH NIH HHS R21 AT003503NCCIH NIH HHS U19 AT002022
6 · The paper itself

Abstract

backgroundTai Chi (TC) is a mind-body exercise that shows potential as an effective and safe intervention for preventing fall-related fractures in the elderly. Few randomized trials have simultaneously evaluated TC's potential to reduce bone loss and improve fall-predictive balance parameters in osteopenic women.

methodsIn a pragmatic randomized trial, 86 post-menopausal osteopenic women, aged 45-70, were recruited from community clinics. Women were assigned to either nine months of TC training plus usual care (UC) vs. UC alone. Primary outcomes were changes between baseline and nine months of bone mineral density (BMD) of the proximal femur and lumbar spine (dual-energy X-ray absorptiometry) and serum markers of bone resorption and formation. Secondary outcomes included quality of life. In a subsample (n = 16), quiet standing fall-predictive sway parameters and clinical balance tests were also assessed. Both intent-to-treat and per-protocol analyses were employed.

resultsFor BMD, no intent-to-treat analyses were statistically significant; however, per protocol analyses (i.e., only including TC participants who completed ≥ 75% training requirements) of femoral neck BMD changes were significantly different between TC and UC (+0.04 vs. -0.98%; P = 0.05). Changes in bone formation markers and physical domains of quality of life were also more favorable in per protocol TC vs. UC (P = 0.05). Changes in sway parameters were significantly improved by TC vs. UC (average sway velocity, P = 0.027; anterior-posterior sway range, P = 0.014). Clinical measures of balance and function showed non-significant trends in favor of TC.

conclusionsTC training offered through existing community-based programs is a safe, feasible, and promising intervention for reducing multiple fracture risks. Our results affirm the value of a more definitive, longer-term trial of TC for osteopenic women, adequately powered to detect clinically relevant effects of TC on attenuation of BMD loss and reduction of fall risk in this population.

trial registrationClinicalTrials.gov: NCT01039012.

Indexed as

Bone DensityOsteogenesisPostural BalanceTai JiAccidental FallsActivities of Daily LivingAdultAgedBiomarkersBone Diseases, MetabolicExercise TherapyFemaleFemur NeckHumansIntention to Treat AnalysisMiddle AgedBiomarkers

Identifiers

PMID22289280
PMCPMC3298524
OpenAlexW2154469799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.