ArticleBehavioral neuroscience2012
An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats.
Article in Behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of early life adversity on male reproductive behavior and the medial preoptic area transcriptome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence.Frontiers in behavioral neuroscience · 2020Review
- The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents.International journal of molecular sciences · 2019Review
- Copulation induces expression of the immediate early gene Arc in mating-relevant brain regions of the male rat.Behavioural brain research · 2019Article
- Differential control of appetitive and consummatory sexual behavior by neuroestrogens in male quail.Hormones and behavior · 2018Review
- Dual action of neuro-estrogens in the regulation of male sexual behavior.General and comparative endocrinology · 2018Review
- Revisiting medial preoptic area plasticity induced in male mice by sexual experience.Scientific reports · 2017Article
- Steroid metabolism in the brain: From bird watching to molecular biology, a personal journey.Hormones and behavior · 2017Review
- Glutamate released in the preoptic area during sexual behavior controls local estrogen synthesis in male quail.Psychoneuroendocrinology · 2017Article
- Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.Behavioral neuroscience · 2012Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Systemic injections of an NMDA antagonist have been shown to impair mating in male rats. One site where glutamate and its NMDA receptors may contribute to mating is the medial preoptic area (MPOA), which is vital for male sexual behavior. Glutamate is released in the MPOA during copulation, and especially at the time of ejaculation. We report here that the NMDA antagonist MK-801, microinjected into the MPOA, impaired copulatory behavior in sexually naïve as well as experienced males. In rats tested both as naïve and after sexual experience, drug treatment produced more profound impairment in naïve males. In addition, MK-801, microinjected into the MPOA before each of 7 noncopulatory exposures to receptive female rats, resulted in copulatory impairments on a drug-free test on Day 8, relative to aCSF-treated rats; their behavior was similar to that of males that had not been preexposed to females. Therefore, NMDA receptors in the MPOA contribute to the control of copulation and stimulus sensitization. Glutamate, acting via NMDA receptors, regulates many neural functions, including neuronal plasticity. This is the first demonstration that a similar mechanism in the MPOA sensitizes male rats to the stimuli from a receptive female, and thereby enhances their behavior.
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