ReviewClinical and experimental immunology2012
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.
Review in Clinical and experimental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 94 citations in OpenAlex.
- CX3CR1(+) B cells show immune suppressor properties.The Journal of biological chemistry · 2014Trial
- Retinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammation.Pediatric research · 2026Article
- Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis.Clinical and experimental immunology · 2025Observational
- Association of Inflammasome Gene Expression Levels with Pathogenesis of Familial Mediterranean Fever in Armenians.International journal of molecular sciences · 2024Article
- What General Neurologists Should Know about Autoinflammatory Syndromes?Brain sciences · 2023Review
- RIPK2: a promising target for cancer treatment.Frontiers in pharmacology · 2023Review
- The everchanging framework of autoinflammation.Internal and emergency medicine · 2021Review
- Retinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiography.Arquivos brasileiros de oftalmologia · 2021Article
- Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery.Integrative medicine (Encinitas, Calif.) · 2020Review
- Does low-density lipoprotein cholesterol induce inflammation? If so, does it matter? Current insights and future perspectives for novel therapies.BMC medicine · 2019Article
- Disease course and treatment effects of a JAK inhibitor in a patient with CANDLE syndrome.Pediatric rheumatology online journal · 2019Article
- Diagnostic utility of a targeted next-generation sequencing gene panel in the clinical suspicion of systemic autoinflammatory diseases: a multi-center study.Rheumatology international · 2019Article
- HSP70 is a negative regulator of NLRP3 inflammasome activation.Cell death & disease · 2019Article
- Pharmacological Inhibitors of the NLRP3 Inflammasome.Frontiers in immunology · 2019Review
- New evidence of connections between increased O-GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus.Clinical and experimental immunology · 2018Article
- Peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in adult-onset familial Mediterranean fever.International ophthalmology · 2018Article
- COPs and POPs Patrol Inflammasome Activation.Journal of molecular biology · 2018Review
- Cardiovascular disease in patients with autoinflammatory syndromes.Rheumatology international · 2018Review
- [Severe acne in autoinflammatory diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2016Article
- NOD-Like Receptors in Infection, Immunity, and Diseases.Yonsei medical journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Autoinflammatory syndromes are disorders characterized by the hyperactivation of the innate immune system in the absence of microbial infection or autoantibody production. Some autoinflammatory syndromes are associated with recurrent episodes of fever and systemic inflammation that are caused by dysregulated activation of inflammasomes, molecular platforms responsible for the activation of caspase-1 and the production of interleukin (IL)-1β. In this review we will discuss the role of IL-1β and the inflammasomes in host defence and how mutations of two genes, NLRP3 and PYRIN, leads to the autoinflammatory syndromes, cryopyrin-associated periodic syndromes (CAPS) and familial Mediterranean fever (FMF). Both CAPS and FMF are characterized by increased inflammasome activity and overproduction of IL-1β which is ultimately responsible for disease manifestations. Importantly, understanding the molecular mechanisms of these syndromes has led to effective treatment for these rare diseases with biological drugs that target IL-1β-mediated signalling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.