ReviewClinical and experimental immunology2012
Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation.
Review in Clinical and experimental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Determinants and impact of calcium oxalate crystal deposition on renal outcomes in acute kidney injury patients.Renal failure · 2024Article
- Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues.Inflammopharmacology · 2024Review
- Transposable elements activation triggers necroptosis in mouse embryonic stem cells.Cell death & disease · 2023Article
- Lipid Peroxidation and Its Role in the Expression of NLRP1a and NLRP3 Genes in Testicular Tissue of Male Rats: a Model of Spinal Cord InjuryIranian biomedical journal · 2018Article
- An update on the role of the inflammasomes in the pathogenesis of kidney diseases.Pediatric nephrology (Berlin, Germany) · 2016Review
- Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever.Frontiers in microbiology · 2016Review
- Efficacy of interleukin-1 targeting treatments in patients with familial mediterranean Fever.Inflammation · 2015Article
- Familial Mediterranean fever; diagnosis, treatment, and complications.Journal of nephropharmacology · 2015Article
- Familial Mediterranean fever: An updated review.European journal of rheumatology · 2014Review
- Intravascular immunity as a key to systemic vasculitis: a work in progress, gaining momentum.Clinical and experimental immunology · 2014Review
- Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.Journal of leukocyte biology · 2013Article
- The role of the immune response in age-related macular degeneration.International journal of inflammation · 2013Article
- Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice.PloS one · 2013Article
- Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.PloS one · 2013Article
- Broadening the translational immunology landscape.Clinical and experimental immunology · 2012Article
- Cytokines in radiobiological responses: a review.Radiation research · 2012Review
- Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.Clinical and experimental immunology · 2012Review
- Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.Clinical and experimental immunology · 2012Review
- DAMP signaling in fungal infections and diseases.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledOTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and molecular platforms that process this signal to trigger an appropriate effector response. Pattern recognition receptors can engage different signalling cascades that lead to proinflammatory gene expression. At the same time, transcription-independent events such as activation of proteases and/or phagocytosis are also initiated. The inflammasome pathway constitutes a signalling platform that leads to the activation of so-called inflammatory caspases, most notably caspase-1, which plays a pivotal role in the cleavage and thus maturation of proinflammatory cytokines, but also in the induction of pyroptosis, a special type of cell death. In this review we elaborate on the currently known inflammasome complexes with a special focus on the mechanism behind their activation. Understanding these mechanisms could provide important information regarding the potential signalling nodes that might be targeted for therapeutic intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.