ArticleThe European journal of neuroscience2012
Cysteine- and glycine-rich protein 1a is involved in spinal cord regeneration in adult zebrafish.
Article in The European journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons.Cell stem cell · 2023Article
- Gene expression patterns associated with caudal fin shape in the cichlidHydrobiologia · 2023Article
- Assaying Optic Nerve Regeneration in Larval Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Gene expression profiling suggests differences in molecular mechanisms of fin elongation between cichlid species.Scientific reports · 2019Article
- Towards a gene regulatory network shaping the fins of the Princess cichlid.Scientific reports · 2018Article
- Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review.Iranian journal of basic medical sciences · 2017Review
- The Adhesion Molecule-Characteristic HNK-1 Carbohydrate Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish.Molecular neurobiology · 2017Article
- The scales and tales of myelination: using zebrafish and mouse to study myelinating glia.Brain research · 2016Review
- Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.American journal of human genetics · 2016Article
- E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish.Frontiers in pharmacology · 2016Article
- Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages.Neural development · 2014Article
- HMGB1 contributes to regeneration after spinal cord injury in adult zebrafish.Molecular neurobiology · 2014Article
- The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.PloS one · 2014Article
- Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation.Neuroscience bulletin · 2013Review
- MeCP2 modulates gene expression pathways in astrocytes.Molecular autism · 2013Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In contrast to mammals, adult zebrafish have the ability to regrow descending axons and gain locomotor recovery after spinal cord injury (SCI). In zebrafish, a decisive factor for successful spinal cord regeneration is the inherent ability of some neurons to regrow their axons via (re)expressing growth-associated genes during the regeneration period. The nucleus of the medial longitudinal fascicle (NMLF) is one of the nuclei capable of regenerative response after SCI. Using microarray analysis with laser capture microdissected NMLF, we show that cysteine- and glycine-rich protein (CRP)1a (encoded by the csrp1a gene in zebrafish), the function of which is largely unknown in the nervous system, was upregulated after SCI. In situ hybridization confirmed the upregulation of csrp1a expression in neurons during the axon growth phase after SCI, not only in the NMLF, but also in other nuclei capable of regeneration, such as the intermediate reticular formation and superior reticular formation. The upregulation of csrp1a expression in regenerating nuclei started at 3 days after SCI and continued to 21 days post-injury, the longest time point studied. In vivo knockdown of CRP1a expression using two different antisense morpholino oligonucleotides impaired axon regeneration and locomotor recovery when compared with a control morpholino, demonstrating that CRP1a upregulation is an important part of the innate regeneration capability in injured neurons of adult zebrafish. This study is the first to demonstrate the requirement of CRP1a for zebrafish spinal cord regeneration.
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Registered trials
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