ArticleJournal of cognitive neuroscience2012
The human ventromedial prefrontal cortex is critical for transitive inference.
Article in Journal of cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Transitivity performance, relational hierarchy knowledge and awareness: results of an instructional framing manipulation.Hippocampus · 2013Trial
- Hippocampal and ventral medial prefrontal activation during retrieval-mediated learning supports novel inference.Neuron · 2012Trial
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- Cognitive Maps in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- Semantic Memory, Traumatic Brain Injury, and the Iceberg Effect: What Deficits May Lie Below the Surface?American journal of speech-language pathology · 2025Review
- Hippocampal systems for event encoding and sequencing during ongoing narrative comprehension.Communications biology · 2025Article
- Article
- Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A generative model of memory construction and consolidation.Nature human behaviour · 2024Article
- Inverse forgetting in unconscious episodic memory.Scientific reports · 2022Article
- Prelimbic cortex maintains attention to category-relevant information and flexibly updates category representations.Neurobiology of learning and memory · 2021Article
- Is ventromedial prefrontal cortex critical for behavior change without external reinforcement?Neuropsychologia · 2019Article
- Different modulation effects of Tai Chi Chuan and Baduanjin on resting-state functional connectivity of the default mode network in older adults.Social cognitive and affective neuroscience · 2019Article
- Specific hippocampal representations are linked to generalized cortical representations in memory.Nature communications · 2018Article
- Ventromedial Prefrontal Cortex Is Necessary for Normal Associative Inference and Memory Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Temporal Proximity Promotes Integration of Overlapping Events.Journal of cognitive neuroscience · 2017Article
- Inferential Learning of Serial Order of Perceptual Categories by Rhesus Monkeys (The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The role of the hippocampus in generalizing configural relationships.Hippocampus · 2017Article
- Memory: Organization and Control.Annual review of psychology · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesized that the ventromedial pFC (vmPFC) is critical for making transitive inferences (e.g., the logical operation that if A > B and B > C, then A > C). To test this, participants with focal vmPFC damage, brain-damaged comparison participants, and neurologically normal participants completed a transitive inference task consisting an ordered set of arbitrary patterns. Participants first learned through trial-and-error the relationships of the patterns (e.g., Pattern A > Pattern B, Pattern B > Pattern C). After initial learning, participants were presented with novel pairings, some of which required transitive inference (e.g., Pattern A > Pattern C from the relationship above). We observed that vmPFC damage led to a specific deficit in transitive inference, suggesting that an intact vmPFC is necessary for making normal transitive inferences. Given the usefulness of transitivity in inferring social relationships, this deficit may be one of the basic features of social conduct problems associated with vmPFC damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.