ArticleJournal of nutrition and metabolism2012
Creatine-kinase- and exercise-related muscle damage implications for muscle performance and recovery.
Article in Journal of nutrition and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 330 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation on the Recovery Kinetics of Performance, Muscle Damage and Neuromuscular Fatigue Indicators, Following Different Protocols for Muscle Power Development
Recovery Kinetics After Different Sprint Training Protocols
The Effect of Protein Hydrolysate Supplementation to Influence the Expression of Systemic Muscle Function Markers Following Resistance Type Exercise in Male Subjects
Penyagolosa Trail Saludable 2025
Delayed Onset Muscle Soreness in the Gastrocnemius Alters Biomechanical, Viscoelastic Properties, and Trunk Endurance in the Posterior Chain Muscles
Who cites it
330 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Temperature-dependent effects of post-exercise cold-water immersion on recovery: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Pooled it
- The Effects of Astaxanthin Supplementation on Exercise Recovery Biomarkers and Exercise Performance: A Systematic Review and Meta-Analysis.Nutrients · 2026Pooled it
- Effects of Tart Cherry Juice Supplementation on Recovery from Exercise-Induced Muscle Damage in Athletes: A Systematic Review and Meta-Analysis.Sports medicine - open · 2026Pooled it
- Pooled it
- Can Compression Garments Reduce the Deleterious Effects of Physical Exercise on Muscle Strength? A Systematic Review and Meta-Analyses.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effect of Blood Flow Restriction Technique on Delayed Onset Muscle Soreness: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Fatigue and Recovery Time Course After Female Soccer Matches: A Systematic Review And Meta-analysis.Sports medicine - open · 2022Pooled it
- Coenzyme QNutrients · 2022Pooled it
- Effect of Caffeine Ingestion on Indirect Markers of Exercise-Induced Muscle Damage: A Systematic Review of Human Trials.Nutrients · 2022Pooled it
- Effects of Vitamin D in Post-Exercise Muscle Recovery. A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Pooled it
- Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.Phytotherapy research : PTR · 2026Trial
- Combined effects of photobiomodulation and osteopathic manipulation on the physical performance of young adults subjected to exercise-induced muscle damage: a randomized placebo-controlled trial.Lasers in medical science · 2026Trial
- Trial
- Scoring and Possession Small-Sided Games Elicit Distinct 48-Hour Muscle Damage and Neuromuscular Responses in Basketball Athletes.Journal of sports science & medicine · 2026Trial
- Recovery with vistula tart cherries following a marathon.European journal of nutrition · 2026Trial
- Trial
- Effects of a Taekwondo-Specific High-Intensity Interval Training Protocol on the Biomarkers of Cardiovascular and Biochemical Recovery in Collegiate Athletes.International journal of medical sciences · 2025Trial
- Time-course of muscular stress and fatigue markers following different soccer small-sided games: evidence from a randomized crossover study.Frontiers in public health · 2025Trial
270 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases. However, there is controversy in the literature concerning its validity in reflecting muscle damage as a consequence of level and intensity of physical exercise. Nonmodifiable factors, for example, ethnicity, age, and gender, can also affect enzyme tissue activity and subsequent CK serum levels. The extent of effect suggests that acceptable upper limits of normal CK levels may need to be reset to recognise the impact of these factors. There is a need for standardisation of protocols and stronger guidelines which would facilitate greater scientific integrity. The purpose of this paper is to examine current evidence and opinion relating to the release of CK from skeletal muscle in response to physical activity and examine if elevated concentrations are a health concern.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.