ArticleBiomicrofluidics2012
Electrotaxis of lung cancer cells in ordered three-dimensional scaffolds.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Gelatin-based porous scaffolds: design concepts, production, and applications in precision regenerative medicine.Materials today. Bio · 2026Review
- The electrical tumor microenvironment: abnormalities and opportunities.Frontiers in oncology · 2026Review
- Glioblastoma U-87 cell electrotaxis is hindered by doxycycline with a concomitant reduction in the matrix metallopeptidase-9 expression.Biochemistry and biophysics reports · 2024Article
- Electrotaxis evokes directional separation of co-cultured keratinocytes and fibroblasts.Scientific reports · 2023Article
- Microfluidic Determination of Distinct Membrane Transport Properties between Lung Adenocarcinoma Cells CL1-0 and CL1-5.Biosensors · 2022Article
- Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients.Frontiers in immunology · 2021Article
- Platelet Deposition Onto Vascular Wall Regulated by Electrical Signal.Frontiers in physiology · 2021Article
- A flow-based microfluidic device for spatially quantifying intracellular calcium ion activity during cellular electrotaxis.Biomicrofluidics · 2019Article
- Use Microfluidic Chips to Study the Phototaxis of Lung Cancer Cells.International journal of molecular sciences · 2019Article
- Probing tumor microtissue formation and epithelial-mesenchymal transition on a well-mesh microchip.Biomicrofluidics · 2019Article
- Engineering 3D approaches to model the dynamic microenvironments of cancer bone metastasis.Bone research · 2018Review
- Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study.Computational and mathematical methods in medicine · 2018Article
- Studying Electrotaxis in Microfluidic Devices.Sensors (Basel, Switzerland) · 2017Review
- Inverse Opal Scaffolds and Their Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2017Review
- Lipid rafts sense and direct electric field-induced migration.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment.Journal of the Royal Society, Interface · 2017Review
- Integration of Curved D-Type Optical Fiber Sensor with Microfluidic Chip.Sensors (Basel, Switzerland) · 2016Article
- Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli.Journal of visualized experiments : JoVE · 2016Article
- Comparison of Chip Inlet Geometry in Microfluidic Devices for Cell Studies.Molecules (Basel, Switzerland) · 2016Article
- Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip.Journal of visualized experiments : JoVE · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we report a new method to incorporate 3D scaffold with electrotaxis measurement in the microfluidic device. The electrotactic response of lung cancer cells in the 3D foam scaffolds which resemble the in vivo pulmonary alveoli may give more insight on cellular behaviors in vivo. The 3D scaffold consists of ordered arrays of uniform spherical pores in gelatin. We found that cell morphology in the 3D scaffold was different from that in 2D substrate. Next, we applied a direct current electric field (EF) of 338 mV/mm through the scaffold for the study of cells' migration within. We measured the migration directedness and speed of different lung cancer cell lines, CL1-0, CL1-5, and A549, and compared with those examined in 2D gelatin-coated and bare substrates. The migration direction is the same for all conditions but there are clear differences in cell morphology, directedness, and migration speed under EF. Our results demonstrate cell migration under EF is different in 2D and 3D environments and possibly due to different cell morphology and/or substrate stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.