ArticleJournal of chemical biology2011
Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?
Article in Journal of chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Production of Protein Hydrolysates with Antioxidant and Antihypertensive Activity from Edible Larvae ofFoods (Basel, Switzerland) · 2025Article
- Promiscuity in Polyphenol-Protein Interactions-Monitoring Protein Conformational Change upon Polyphenol-Protein Binding by Nano-Differential Fluorimetry (Nano-DSF).Molecules (Basel, Switzerland) · 2025Article
- Children of Nature: Thoughts on Targeted and Untargeted Analytical Approaches to Decipher Polyphenol Reactivity in Food Processing and Metabolism.Journal of agricultural and food chemistry · 2024Review
- Inhibition of MurA Enzyme fromACS omega · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose-response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.
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