Evidence map›Paper›PMID 22287989›Full record

ArticleBiomedical imaging and intervention journal2011

Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review.

M Al Moudi, Z Sun, N Lenzo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical imaging and intervention journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020
    Guideline
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. SPECT/CT and PET/CT, related radiopharmaceuticals, and areas of application and comparison.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer.Endocrinology and metabolism (Seoul, Korea) · 2020
    Article
  13. Article
  14. Comorbid conditions in individuals assessed by SPECT: Study of a reference cardiology center in Mexico City.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  15. Searching for novel PET radiotracers: imaging cardiac perfusion, metabolism and inflammation.American journal of nuclear medicine and molecular imaging · 2018
    Review
  16. SPECT vs CT: CT is not the first line test for the diagnosis and prognosis of stable coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013
    Article
  17. Transient ischemic dilation in SPECT myocardial perfusion imaging for prediction of severe coronary artery disease in diabetic patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013
    Article
  18. Sudden cardiac death after repair of anomalous origin of left coronary artery from right sinus of Valsalva with an interarterial course : Case report and review of the literature.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2012
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M Al MoudiDiscipline of Medical Imaging, Curtin University of Technology, Perth, Western Australia, Australia.
Z Sun
N Lenzo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease, based on a systematic review. MATERIAL AND

methodsA search of PubMed/Medline and Sciencedirect databases in the English-language literature published over the last 24 years was performed. Only studies with at least 10 patients comparing SPECT, PET or combined PET/CT with invasive coronary angiography in the diagnosis of coronary artery disease (50% stenosis) were included for analysis. Sensitivities and specificities estimates pooled across studies were analysed using a Chi-square test.

resultsTwenty-five studies met the selection criteria and were included for the analysis. Ten studies were performed with SPECT alone; while another six studies were performed with PET alone. Five studies were carried out with both PET and SPECT modalities, and the remaining four studies were investigated with integrated PET-CT. The mean value of sensitivity, specificity and accuracy of these imaging modalities for the diagnosis of coronary artery disease was 82% (95%CI: 76 to 88), 76% (95%CI: 70 to 82) and 83% (95%CI: 77 to 89) for SPECT; 91% (95%CI: 85 to 97), 89% (95%CI: 83 to 95) and 89% (95%CI: 83 to 95) for PET; and 85% (95%CI: 79 to 90), 83% (95%CI: 77 to 89) and 88% (95%CI: 82 to 94) for PET/CT, respectively. The diagnostic accuracy of these imaging modalities was dependent on the radiotracers used in these studies, with ammonia resulting in the highest diagnostic value.

conclusionOur review shows that PET has high diagnostic value for diagnosing coronary artery disease, and this indicates that it is a valuable technique for both detection and prediction of coronary artery disease.

Indexed as

computed tomographyCoronary artery diseasediagnostic valuepositron emission tomographysingle photon emission computed tomography

Identifiers

PMID22287989
PMCPMC3265156

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.