ArticleJournal of tropical medicine2012
On Programmed Cell Death in Plasmodium falciparum: Status Quo.
Article in Journal of tropical medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Article
- Isolation and characterization ofAntimicrobial agents and chemotherapy · 2025Article
- Trio fluorophore-based phenotypic assay for the detection of artemisinin-induced growth-arrested Plasmodium falciparum in human erythrocytes.Scientific reports · 2024Article
- Transcriptional network constituted of CBP, Ku70, NOX2, and BAX prevents the cell death of necrosis, paraptosis, and apoptosis in human melanoma.Cell death discovery · 2021Article
- High-Content Screening of the Medicines for Malaria Venture Pathogen Box for Plasmodium falciparum Digestive Vacuole-Disrupting Molecules Reveals Valuable Starting Points for Drug Discovery.Antimicrobial agents and chemotherapy · 2018Article
- Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues.Malaria journal · 2016Article
- Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.Antimicrobial agents and chemotherapy · 2015Article
- Sunlight inhibits growth and induces markers of programmed cell death in Plasmodium falciparum in vitro.Malaria journal · 2015Article
- Programmed death in a unicellular organism has species-specific fitness effects.Biology letters · 2014Article
- Turning up the heat: heat stress induces markers of programmed cell death in Plasmodium falciparum in vitro.Cell death & disease · 2013Article
- The first suicides: a legacy inherited by parasitic protozoans from prokaryote ancestors.Parasites & vectors · 2013Review
- Article
- Cell death in parasitic protozoa: regulated or incidental?Nature reviews. Microbiology · 2013Review
- A role for programmed cell death in the microbial loop.PloS one · 2013Article
- Autophagy in Apicomplexa: a life sustaining death mechanism?Trends in parasitology · 2012Article
- Variation in apoptosis mechanisms employed by malaria parasites: the roles of inducers, dose dependence and parasite stages.Malaria journal · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conflicting arguments and results exist regarding the occurrence and phenotype of programmed cell death (PCD) in the malaria parasite Plasmodium falciparum. Inconsistencies relate mainly to the number and type of PCD markers assessed and the different methodologies used in the studies. In this paper, we provide a comprehensive overview of the current state of knowledge and empirical evidence for PCD in the intraerythrocytic stages of P. falciparum. We consider possible reasons for discrepancies in the data and offer suggestions towards more standardised investigation methods in this field. Furthermore, we present genomic evidence for PCD machinery in P. falciparum. We discuss the potential adaptive or nonadaptive role of PCD in the parasite life cycle and its possible exploitation in the development of novel drug targets. Lastly, we pose pertinent unanswered questions concerning the PCD phenomenon in P. falciparum to provide future direction.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.