ArticleFrontiers in neuroengineering2011
Sequential mechanisms underlying concentration invariance in biological olfaction.
Article in Frontiers in neuroengineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Titrating the Smell of Fear: Initial Evidence for Dose-Invariant Behavioral, Physiological, and Neural Responses.Psychological science · 2021Trial
- Odour learning concentration influences concentration range of conditioned response in newborn rabbits.Scientific reports · 2025Article
- Order code in the olfactory system.bioRxiv : the preprint server for biology · 2025Article
- Mice and humans evaluate odor stimulus strength using common psychophysical principles.bioRxiv : the preprint server for biology · 2025Article
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2025Article
- Odor encoding by fine-timescale spike synchronization patterns in the olfactory bulb.Journal of neurophysiology · 2025Article
- Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.iScience · 2025Article
- Heterogeneous quantization regularizes spiking neural network activity.Scientific reports · 2025Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Non-synaptic interactions between olfactory receptor neurons, a possible key feature of odor processing in flies.PLoS computational biology · 2021Article
- A physicochemical model of odor sampling.PLoS computational biology · 2021Article
- Stimulus Control of Odorant Concentration: Pilot Study of Generalization and Discrimination of Odor Concentration in Canines.Animals : an open access journal from MDPI · 2021Article
- Transfer of Odor Perception From the Retronasal to the Orthonasal Pathway.Chemical senses · 2021Article
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Rapid online learning and robust recall in a neuromorphic olfactory circuit.Nature machine intelligence · 2020Article
- A Systematic Framework for Olfactory Bulb Signal Transformations.Frontiers in computational neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Concentration invariance-the capacity to recognize a given odorant (analyte) across a range of concentrations-is an unusually difficult problem in the olfactory modality. Nevertheless, humans and other animals are able to recognize known odors across substantial concentration ranges, and this concentration invariance is a highly desirable property for artificial systems as well. Several properties of olfactory systems have been proposed to contribute to concentration invariance, but none of these alone can plausibly achieve full concentration invariance. We here propose that the mammalian olfactory system uses at least six computational mechanisms in series to reduce the concentration-dependent variance in odor representations to a level at which different concentrations of odors evoke reasonably similar representations, while preserving variance arising from differences in odor quality. We suggest that the residual variance then is treated like any other source of stimulus variance, and categorized appropriately into "odors" via perceptual learning. We further show that naïve mice respond to different concentrations of an odorant just as if they were differences in quality, suggesting that, prior to odor categorization, the learning-independent compensatory mechanisms are limited in their capacity to achieve concentration invariance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.