ArticleFrontiers in human neuroscience2011
A role for locus coeruleus in Parkinson tremor.
Article in Frontiers in human neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Risk of Valproic Acid-Related Tremor: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- The Noradrenergic Brain in Parkinson's Disease.Current neurology and neuroscience reports · 2026Review
- GABAergic dysfunction in Parkinson's disease: insights from in vivo proton magnetic resonance spectroscopy.NPJ Parkinson's disease · 2026Article
- Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control.NPJ Parkinson's disease · 2026Article
- Differentiating tremor-dominant parkinson's disease from essential tremor using neuromelanin- sensitive imaging and T1w/T2w ratio.NPJ Parkinson's disease · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Noradrenergic tuning of arousal is coupled to movement transitions.Cell reports · 2025Article
- Data-Driven Subtypes of Parkinson Disease Based on Dopamine Responsiveness.CNS neuroscience & therapeutics · 2025Article
- Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex.Cell reports · 2025Article
- Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Longitudinal Analysis of Retinal Microvascular and Choroidal Imaging Parameters in Parkinson's Disease Compared with Controls.Ophthalmology science · 2023Article
- Article
- Levodopa responsiveness in Parkinson's disease: harnessing real-life experience with machine-learning analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- The Contribution of Noradrenergic Activity to Anxiety-Induced Freezing of Gait.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson's disease.Brain communications · 2022Review
- Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy.PloS one · 2022Article
- The Molecular Neuroimaging of Tremor.Current neurology and neuroscience reports · 2021Review
- Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts.NPJ Parkinson's disease · 2021Article
- Revisiting the L-Dopa Response as a Predictor of Motor Outcomes After Deep Brain Stimulation in Parkinson's Disease.Frontiers in human neuroscience · 2021Article
- Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype.Brain : a journal of neurology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease (PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [(123)I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane (FP-CIT). The intensity of tremor (i.e., the power of Electromyography [EMG] signals), but not its frequency, significantly increased during the task. In six subjects, tremor appeared selectively during the task. In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). This study suggests a role of the LC in Parkinson tremor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.