ArticleMedical hypotheses and research : MHR2008
CONTRACTILITY OF THE RENAL GLOMERULUS AND MESANGIAL CELLS: LINGERING DOUBTS AND STRATEGIES FOR THE FUTURE.
Article in Medical hypotheses and research : MHR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Polyphenol-Rich Mangosteen Pericarp Extract Attenuates Metabolic and Reproductive Dysfunction in High-fat Diet and Streptozotocin-induced Obese-Diabetic Male Rats: A Preliminary Study.Applied biochemistry and biotechnology · 2026Article
- Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation.Journal of biological engineering · 2022Review
- Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases.International journal of molecular sciences · 2021Review
- Decoding the differentiation of mesenchymal stem cells into mesangial cells at the transcriptomic level.BMC genomics · 2020Article
- The Influence of a Nanopatterned Scaffold that Mimics Abnormal Renal Mesangial Matrix on Mesangial Cell Behavior.International journal of molecular sciences · 2019Article
- Renal Tissue Damages and Its Antioxidant Status Improved by Crab Shell Extract in Streptozotocin-induced Diabetic Rat.Advanced biomedical research · 2019Article
- Quantitative characterization of glomerular fibrosis with magnetic resonance imaging: a feasibility study in a rat glomerulonephritis model.American journal of physiology. Renal physiology · 2018Article
- Hyperfiltration-associated biomechanical forces in glomerular injury and response: Potential role for eicosanoids.Prostaglandins & other lipid mediators · 2017Review
- Advanced glycation end products and oxidative stress in type 2 diabetes mellitus.Biomolecules · 2015Review
- A potential role for mechanical forces in the detachment of podocytes and the progression of CKD.Journal of the American Society of Nephrology : JASN · 2015Review
- Chaperonin-containing t-complex protein-1 subunit β as a possible biomarker for the phase of glomerular hyperfiltration of diabetic nephropathy.Disease markers · 2015Article
- The glomerulus: the sphere of influence.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- Real-time Imaging of Ca-handling in Intact Renal Glomeruli Using Confocal Microscopy.Medical hypotheses and research : MHR · 2009Article
- Studying channel and receptor physiology in podocytes.Kidney international · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Kidneys can be divided into four components: glomeruli, tubules, interstitium and blood vessels. The renal glomerulus consists of a network of capillaries covered with epithelial cells called podocytes. The entire glomerular tuft is structurally supported by mesangial cells which are contractile in nature and resemble vascular smooth muscle cells. Mesangial cells are secretory, producing growth factors and matrix proteins which have a role in both normal glomerular development and in pathologic states. They have also been shown to take the role of macrophages. The importance of mesangial cell contraction to glomerular physiology remains debated. It is postulated that mesangial cell contraction can attenuate the glomerular filtration rate by decreasing the renal ultrafiltration coefficient through a decrease in capillary surface area and capillary permeability. The physiology of mesangial cell contraction has been studied primarily utilizing cultured cells. The physiological status of receptors and ion channels may be doubtful, however, given the phenotypic changes cells are known to acquire in culture conditions. The contractility of renal glomeruli has been less well studied. In this report, we review the available data regarding the contractility of mesangial cell and of renal glomeruli. Moreover, we suggest newer techniques that can be used with whole glomeruli, thereby improving upon the data collected using previous techniques and cultured cells.
Identifiers
22287940PMC3266944W122956322What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.