ArticleInternational journal of nanomedicine2012
Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Effectiveness of avocado leaf extract (F1000Research · 2022Article
- Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhance tumor cell killing.International journal of pharmaceutics · 2018Article
- Polymerization-Induced Phase Separation Formation of Structured Hydrogel Particles via Microfluidics for Scar Therapeutics.Scientific reports · 2018Article
- Tunable delayed controlled release profile from layered polymeric microparticles.Journal of materials chemistry. B · 2017Article
- Sorafenib and 2,3,5-triiodobenzoic acid-loaded imageable microspheres for transarterial embolization of a liver tumor.Scientific reports · 2017Article
- Synthesis of self-assembled IL-1Ra-presenting nanoparticles for the treatment of osteoarthritis.Journal of biomedical materials research. Part A · 2016Article
- Patterning Biomaterials for the Spatiotemporal Delivery of Bioactive Molecules.Frontiers in bioengineering and biotechnology · 2016Review
- The preparation of core/shell structured microsphere of multi first-line anti-tuberculosis drugs and evaluation of biological safety.International journal of clinical and experimental medicine · 2015Article
- Preparation and in vitro/in vivo characterization of enteric-coated nanoparticles loaded with the antihypertensive peptide VLPVPR.International journal of nanomedicine · 2014Article
- IL-1Ra and its delivery strategies: inserting the association in perspective.Pharmaceutical research · 2013Review
- Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of tumors.International journal of nanomedicine · 2013Article
- pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein.International journal of nanomedicine · 2013Article
- Novel preparation method for sustained-release PLGA microspheres using water-in-oil-in-hydrophilic-oil-in-water emulsion.International journal of nanomedicine · 2013Article
- Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method.International journal of nanomedicine · 2012Article
- Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2.International journal of nanomedicine · 2012Article
- Preparation of bioactive interferon alpha-loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion.International journal of nanomedicine · 2012Article
- Composite microsphere-functionalized scaffold for the controlled release of small molecules in tissue engineering.Journal of tissue engineeringArticle
Corrections and comments
- Retraction · 2018-04-19Duplication of/in Image ·
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to address preserved protein bioactivities and protein sustained-release problems, a method for preparing double-walled microspheres with a core (protein-loaded nanoparticles with a polymer-suspended granule system-formed core) and a second shell (a polymer-formed shell) for controlled drug release and preserved protein bioactivities has been developed using (solid-in-oil phase-in-hydrophilic oil-in-water (S/O/O(h)/W)) phases. The method, based on our previous microsphere preparation method (solid-in-oil phase-in-hydrophilic oil-in-water (S/O/O(h)/W), employs different concentric poly(D,L-lactide-co-glycolide), poly(D,L-lactide), and protein-loaded nanoparticles to produce a suspended liquid which then self-assembles to form shell-core microspheres in the hydrophilic oil phase, which are then solidified in the water phase. Variations in the preparation parameters allowed complete encapsulation by the shell phase, including the efficient formation of a poly(D,L-lactide) shell encapsulating a protein-loaded nanoparticle-based poly(D,L-lactide-co-glycolide) core. This method produces core-shell double-walled microspheres that show controlled protein release and preserved protein bioactivities for 60 days. Based upon these results, we concluded that the core-shell double-walled microspheres might be applied for tissue engineering and therapy for chronic diseases, etc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.