ArticleJournal of biomedicine & biotechnology2012
Proteomic analysis of Trypanosoma cruzi epimastigotes subjected to heat shock.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Article
- Meta-transcriptomic identification of Trypanosoma spp. in native wildlife species from Australia.Parasites & vectors · 2020Article
- Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei.Nucleic acids research · 2019Article
- Identification ofFrontiers in endocrinology · 2019Article
- Development of a Trypanosoma cruzi strain typing assay using MS2 peptide spectral libraries (Tc-STAMS2).PLoS neglected tropical diseases · 2018Article
- A Brief View of the Surface Membrane Proteins fromJournal of parasitology research · 2017Review
- Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection.PLoS pathogens · 2016Article
- Article
- Unveiling the Trypanosoma cruzi Nuclear Proteome.PloS one · 2015Article
- Dealing with environmental challenges: mechanisms of adaptation in Trypanosoma cruzi.Research in microbiology · 2014Review
- Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosoma brucei.Journal of parasitology research · 2014Article
- Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger protein.PLoS pathogens · 2013Article
- Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes.The Journal of eukaryotic microbiologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trypanosoma cruzi is exposed to sudden temperature changes during its life cycle. Adaptation to these variations is crucial for parasite survival, reproduction, and transmission. Some of these conditions may change the pattern of genetic expression of proteins involved in homeostasis in the course of stress treatment. In the present study, the proteome of T. cruzi epimastigotes subjected to heat shock and epimastigotes grow normally was compared by two-dimensional gel electrophoresis followed by mass spectrometry for protein identification. Twenty-four spots differing in abundance were identified. Of the twenty-four changed spots, nineteen showed a greater intensity and five a lower intensity relative to the control. Several functional categories of the identified proteins were determined: metabolism, cell defense, hypothetical proteins, protein fate, protein synthesis, cellular transport, and cell cycle. Proteins involved in the interaction with the cellular environment were also identified, and the implications of these changes are discussed.
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