ArticleCurrent trends in immunology2011
Phenotype and function of regulatory T cells in the genital tract.
Article in Current trends in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Poor Lymphocyte Infiltration to Primary Tumors in Acral Lentiginous Melanoma and Mucosal Melanoma Compared to Cutaneous Melanoma.Frontiers in oncology · 2020Pooled it
- Review
- Mesenchymal stem cells prevent overwhelming inflammation and reduce infection severity via recruiting CXCR3Clinical & translational immunology · 2020Article
- CCR7 Deficiency Allows Accelerated Clearance ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Multiple Sclerosis: Immunopathology and Treatment Update.Brain sciences · 2017Review
- Characteristics of HIV target CD4 T cells collected using different sampling methods from the genital tract of HIV seronegative women.PloS one · 2017Article
- Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal Immunity.AIDS research and human retroviruses · 2015Article
- Depot medroxyprogesterone acetate increases immune cell numbers and activation markers in human vaginal mucosal tissues.AIDS research and human retroviruses · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
T cells with the specialized ability to suppress both adaptive and innate immune responses have been identified and called T regulatory cells (Tregs). The primary function of Tregs is to maintain a balance between immunity (foreign Ag) and tolerance (self Ag) to tissues. Tregs prevent autoimmune disease, maintain immune homeostasis and modulate protective responses against infection. Tregs function in two ways; 1) limiting the magnitude of effector responses which influence the adequate control of infection and 2) control collateral tissue damage caused by vigorous antimicrobial responses against pathogens. Initially, the immune suppressive ability of CD4 T cells was predicted by expression of the forkhead box p3 (Foxp3) transcription factor. However, many reports have demonstrated immune suppressive function in an array of other T cells which include iT(R)35, CD8+, NKT cells, especially in mucosal tissues. The immune suppressive mechanisms of Tregs include contact-dependent, cytokine secretion and regulation of immune cell migration. The expanded group of Tregs is crucial for protecting the function of mucosal tissues such as the gut, respiratory and genital tracts, as these tissues are routinely exposed to foreign pathogens.
Identifiers
22287829PMC3266607W1881023890What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.