ReviewBriefings in bioinformatics2012
Identification of aberrant pathways and network activities from high-throughput data.
Review in Briefings in bioinformatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Exploring autophagy-related prognostic genes of Alzheimer's disease based on pathway crosstalk analysis.Bosnian journal of basic medical sciences · 2022Article
- Characteristics of genomic mutations and signaling pathway alterations in thymic epithelial tumors.Annals of translational medicine · 2021Article
- System, Method and Software for Calculation of a Cannabis Drug Efficiency Index for the Reduction of Inflammation.International journal of molecular sciences · 2020Article
- Multi-omic Pathway and Network Analysis to Identify Biomarkers for Hepatocellular Carcinoma.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019Article
- Network-Based Protein Biomarker Discovery Platforms.Genomics & informatics · 2016Review
- A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis.Proteomics · 2016Article
- Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity.Scientific reports · 2015Article
- Data integration in biological research: an overview.Journal of biological research (Thessalonike, Greece) · 2015Review
- Applications of systems approaches in the study of rheumatic diseases.The Korean journal of internal medicine · 2015Review
- Data- and knowledge-based modeling of gene regulatory networks: an update.EXCLI journal · 2015Review
- Pathway and network approaches for identification of cancer signature markers from omics data.Journal of Cancer · 2015Review
- Identification of functional modules by integration of multiple data sources using a Bayesian network classifier.Circulation. Cardiovascular genetics · 2014Article
- Multiscale models of breast cancer progression.Annals of biomedical engineering · 2012Review
- Identifying aberrant pathways through integrated analysis of knowledge in pharmacogenomics.Bioinformatics (Oxford, England) · 2012Article
- Genomics and bioinformatics of Parkinson's disease.Cold Spring Harbor perspectives in medicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many complex diseases such as cancer are associated with changes in biological pathways and molecular networks rather than being caused by single gene alterations. A major challenge in the diagnosis and treatment of such diseases is to identify characteristic aberrancies in the biological pathways and molecular network activities and elucidate their relationship to the disease. This review presents recent progress in using high-throughput biological assays to decipher aberrant pathways and network activities. In particular, this review provides specific examples in which high-throughput data have been applied to identify relationships between diseases and aberrant pathways and network activities. The achievements in this field have been remarkable, but many challenges have yet to be addressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.