ArticleJournal of immunology (Baltimore, Md. : 1950)2012
MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 73 citations in OpenAlex.
- Interplay between innate-like T-cells and microRNAs in cancer immunity.Discover oncology · 2025Review
- AKT Isoforms in the Immune Response in Cancer.Current topics in microbiology and immunology · 2022Article
- microRNA dynamic expression regulates invariant NKT cells.Cellular and molecular life sciences : CMLS · 2021Review
- Identification of differentially expressed miRNAs in human cells infected with different Zika virus strains.Archives of virology · 2021Article
- miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance.Clinical & translational immunology · 2021Article
- Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge.Nature reviews. Immunology · 2020Review
- Comprehensive analysis of circRNA expression profiles and circRNA-associated competing endogenous RNA networks in the development of mouse thymus.Journal of cellular and molecular medicine · 2020Article
- High Frequency of Gamma Interferon-Producing PLZFJournal of virology · 2020Article
- Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study.BioMed research international · 2020Article
- Role of miRNAs in Normal and Myasthenia Gravis Thymus.Frontiers in immunology · 2020Review
- MicroRNA-155 ControlsFrontiers in cell and developmental biology · 2020Article
- miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Development of Unconventional T Cells Controlled by MicroRNA.Frontiers in immunology · 2019Review
- A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset.Nature communications · 2018Article
- Development of mucosal-associated invariant T cells.Immunology and cell biology · 2018Review
- Metazoan MicroRNAs.Cell · 2018Review
- Invariant natural killer T-cell development and function with loss of microRNA-155.Immunology · 2018Article
- MicroRNA Functions in Thymic Biology: Thymic Development and Involution.Frontiers in immunology · 2018Review
- How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
CD1d-restricted Vα14 invariant NKT (iNKT) cells play an important role in the regulation of diverse immune responses. MicroRNA-mediated RNA interference is emerging as a crucial regulatory mechanism in the control of iNKT cell differentiation and function. Yet, roles of specific microRNAs in the development and function of iNKT cells remain to be further addressed. In this study, we identified the gradually increased expression of microRNA-150 (miR-150) during the maturation of iNKT cells in thymus. Using miR-150 knockout (KO) mice, we found that miR-150 deletion resulted in an interruption of iNKT cell final maturation in both thymus and periphery. Upon activation, iNKT cells from miR-150KO mice showed significantly increased IFN-γ production compared with wild-type iNKT cells. Bone marrow-transferring experiments demonstrated the cell-intrinsic characteristics of iNKT cell maturation and functional defects in mice lacking miR-150. Furthermore, miR-150 target c-Myb was significantly upregulated in miR-150KO iNKT cells, which potentially contribute to iNKT cell defects in miR-150KO mice. Our data define a specific role of miR-150 in the development and function of iNKT cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.