ArticleNucleic acids research2012
A novel non-homologous recombination-mediated mechanism for Escherichia coli unilateral flagellar phase variation.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Virulence regulation in the fish pathogenFrontiers in cellular and infection microbiology · 2026Review
- Aptamers and Aptamer-Coupled Biosensors to Detect Water-Borne Pathogens.Frontiers in microbiology · 2021Review
- E. coli diversity: low in colorectal cancer.BMC medical genomics · 2020Article
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- Escherichia coli H-Genotyping PCR: a Complete and Practical Platform for Molecular H Typing.Journal of clinical microbiology · 2018Article
- No evidence for a bovine mastitis Escherichia coli pathotype.BMC genomics · 2017Article
- Turn Up the Heat-Food and ClinicalFrontiers in microbiology · 2017Article
- Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae.BMC genomics · 2016Article
- Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection.Microbiology spectrum · 2015Review
- Bacterial genome instability.Microbiology and molecular biology reviews : MMBR · 2014Review
- The large universal Pantoea plasmid LPP-1 plays a major role in biological and ecological diversification.BMC genomics · 2012Article
- Developing insights into the mechanisms of evolution of bacterial pathogens from whole-genome sequences.Future microbiology · 2012Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flagella contribute to the virulence of bacteria through chemotaxis, adhesion to and invasion of host surfaces. Flagellar phase variation is believed to facilitate bacterial evasion of the host immune response. In this study, the flnA gene that encodes Escherichia coli H17 flagellin was examined by whole genome sequencing and genetic deletion analysis. Unilateral flagellar phase variation has been reported in E. coli H3, H47 and H17 strains, although the mechanism for phase variation in the H17 strain has not been previously understood. Analysis of phase variants indicated that the flagellar phase variation in the H17 strain was caused by the deletion of an ∼35 kb DNA region containing the flnA gene from diverse excision sites. The presence of covalently closed extrachromosomal circular forms of this excised 35 kb region was confirmed by the two-step polymerase chain reaction. The deletion and complementation test revealed that the Int1157 integrase, a tyrosine recombinase, mediates the excision of this region. Unlike most tyrosine recombinases, Int1157 is suggested to recognize diverse sites and mediate recombination between non-homologous DNA sequences. This is the first report of non-homologous recombination mediating flagellar phase variation.
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