ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Sympathetic activation and nitric oxide function in early hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2023Pooled it
- Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- Autonomic blockade improves insulin sensitivity in obese subjects.Hypertension (Dallas, Tex. : 1979) · 2014Trial
- Central hemodynamics in prehypertension: effect of the β-adrenergic antagonist nebivolol.Journal of clinical hypertension (Greenwich, Conn.) · 2013Trial
- Physical Activity and Hypertension.Reviews in cardiovascular medicine · 2022Review
- Clinical Relevance of the Sympathetic-Vascular Interactions in Health and Disease.Biomedicines · 2021Review
- Pharmacologic treatment of orthostatic hypotension.Autonomic neuroscience : basic & clinical · 2020Review
- Nutraceuticals as a potential adjunct therapy toward improving vascular health in CKD.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- The Pharmacology of Autonomic Failure: From Hypotension to Hypertension.Pharmacological reviews · 2017Review
- Cardiac autonomic neuropathy risk estimated by sudomotor function and arterial stiffness in Chinese subjects.Journal of human hypertension · 2016Article
- Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness.The Journal of physiology · 2016Review
- Endothelial nitric oxide synthase gene polymorphism is associated with Legg-Calvé-Perthes disease.Experimental and therapeutic medicine · 2016Article
- Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity.American journal of physiology. Heart and circulatory physiology · 2015Article
- The relationship of plasma catestatin concentrations with metabolic and vascular parameters in untreated hypertensive patients: Influence on high-density lipoprotein cholesterol.Anatolian journal of cardiology · 2015Observational
- The Relationship between Vascular Function and the Autonomic Nervous System.Annals of vascular diseases · 2014Review
- Association of EZSCAN values with arterial stiffness in individuals without diabetes or cardiovascular disease.PloS one · 2014Article
- Adolescent blood pressure hyperreactors have a higher reactive hyperemic index at the fingertip.European journal of applied physiology · 2013Article
- Management approaches to hypertension in autonomic failure.Current opinion in nephrology and hypertension · 2012Review
- Sympathetic regulation of vascular function in health and disease.Frontiers in physiology · 2012Article
- Blood Pressure and Autonomic Changes From 12-Weeks of Yoga-Based Slow Breathing Exercises.Global advances in integrative medicine and healthArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to determine if tonic restrain of blood pressure by nitric oxide (NO) is impaired early in the development of hypertension. Impaired NO function is thought to contribute to hypertension, but it is not clear if this is explained by direct effects of NO on vascular tone or indirect modulation of sympathetic activity. We determined the blood pressure effect of NO synthase inhibition with N(ω)-monomethyl-l-arginine (L-NMMA) during autonomic blockade with trimethaphan to eliminate baroreflex buffering and NO modulation of autonomic tone. In this setting, impaired NO modulation of vascular tone would be reflected as a blunted pressor response to L-NMMA. We enrolled a total of 66 subjects (39 ± 1.3 yr old, 30 females), 20 normotensives, 20 prehypertensives (blood pressure between 120/80 and 140/90 mmHg), 17 hypertensives, and 9 smokers (included as "positive" controls of impaired NO function). Trimethaphan normalized blood pressure in hypertensives, suggesting increased sympathetic tone contributing to hypertension. In contrast, L-NMMA produced similar increases in systolic blood pressure in normal, prehypertensive, and hypertensive subjects (31 ± 2, 32 ± 2, and 30 ± 3 mmHg, respectively), whereas the response of smokers was blunted (16 ± 5 mmHg, P = 0.012). Our results suggest that sympathetic activity plays a role in hypertension. NO tonically restrains blood pressure by ∼30 mmHg, but we found no evidence of impaired modulation by NO of vascular tone contributing to the early development of hypertension. If NO deficiency contributes to hypertension, it is likely to be through its modulation of the autonomic nervous system, which was excluded in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.