ArticleSocial cognitive and affective neuroscience2013
The neuroanatomical correlates of cognitive insight in schizophrenia.
Article in Social cognitive and affective neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Functional Neural Correlates of Anosognosia in Mild Cognitive Impairment and Alzheimer's Disease: a Systematic Review.Neuropsychology review · 2019Pooled it
- Cognitive insight in patients with depression and non-suicidal self-injury.Frontiers in psychology · 2026Article
- Insight in obsessive-compulsive disorder: conception, clinical characteristics, neuroimaging, and treatment.Psychoradiology · 2023Review
- Neural and Behavioral Correlates of Impaired Insight and Self-Awareness in Substance Use Disorder.Current behavioral neuroscience reports · 2021Article
- Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [Neuropsychiatric disease and treatment · 2021Article
- Brain Structural Correlates of Metacognition in First-Episode Psychosis.Schizophrenia bulletin · 2020Article
- Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naïve adults with obsessive-compulsive disorder.NeuroImage. Clinical · 2019Article
- The impact of cognitive insight, self-stigma, and medication compliance on the quality of life in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2018Article
- Right Frontotemporal Cortex Mediates the Relationship between Cognitive Insight and Subjective Quality of Life in Patients with Schizophrenia.Frontiers in psychiatry · 2018Article
- Article
- Thinking about thinking: A coordinate-based meta-analysis of neuroimaging studies of metacognitive judgements.Brain and neuroscience advances · 2018Review
- A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey.Developmental neurobiology · 2017Review
- The metabolic basis of cognitive insight in psychosis: A positron emission tomography study.PloS one · 2017Article
- Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia.World journal of psychiatry · 2016Article
- Insight and psychosis: Functional and anatomical brain connectivity and self-reflection in Schizophrenia.Human brain mapping · 2015Article
- Assessing and improving clinical insight among patients "in denial".JAMA psychiatry · 2015Article
- Impaired insight into illness and cognitive insight in schizophrenia spectrum disorders: resting state functional connectivity.Schizophrenia research · 2014Article
- The structural neuroanatomy of metacognitive insight in schizophrenia and its psychopathological and neuropsychological correlates.Human brain mapping · 2014Article
- Anosognosia in schizophrenia: hidden in plain sight.Innovations in clinical neuroscience · 2014Article
- Cognitive insight in Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insight has been mostly studied from a clinical perspective. Recently, attention moved to cognitive insight or the ability to monitor and correct one's erroneous convictions. Here, we investigated the neuroanatomical correlates of cognitive insight. We administered the Beck cognitive insight scale to 45 outpatients with a schizophrenia diagnosis and 45 age- and gender-matched healthy control subjects who underwent a MRI investigation, including high-resolution volumetric and diffusion tensor imaging sequences. Gray and white matter volume, mean diffusivity and fractional anisotropy were used as dependent variables and were analyzed on a voxel-by-voxel basis with reference to the cognitive insight indexes. Self-reflectiveness was positively related to gray matter volume of the right ventro-lateral prefrontal cortex (VLPFC). No statistically significant results emerged from the DTI analyses, and no significant relationships were found for self-certainty and global cognitive insight. Reduced self-reflectiveness is related to a reduced volume of the VLPFC, an area involved in generating and maintaining in working memory different hypotheses about the self. This line of research focusing on the metacognitive features of insight in schizophrenia can provide relevant information to identify patients who are most vulnerable to lack of insight and develop effective cognitive therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.