Evidence map›Paper›PMID 22287036›Full record

ReviewLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2012

Development of organ-specific donor risk indices.

Sanjeev K Akkina, Sumeet K Asrani, Yi Peng, Peter Stock, W Ray Kim, Ajay K Israni

Registry-linked trialAbstract readReview
In one paragraph

Review in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04246307 (Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG ® Viscoelastic Tests), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04246307 unknown statusnot on this mapstarted 2020, after this paper: background citation

Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG ® Viscoelastic Tests

TypeobservationalSponsorSemmelweis UniversityRan2020 to 2022Enrolled50ConditionsHaemostasis DisordersArmsTEG® and ClotPro® parameters
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Reduction in Racial and Ethnic Disparity in Survival Following Liver Transplant for Hepatocellular Carcinoma in the Direct-acting Antiviral Era.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Changes in Discard Rate After the Introduction of the Kidney Donor Profile Index (KDPI).American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Article
  11. Article
  12. Lung Quality and Utilization in Controlled Donation After Circulatory Determination of Death Within the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Article
  13. Recipient Criteria Predictive of Graft Failure in Kidney Transplantation.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016
    Article
  14. The corrected donor age for hepatitis C virus-infected liver transplant recipients.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2015
    Article
  15. Article
  16. Article
  17. Hepatic artery and biliary complications in liver transplant recipients undergoing pretransplant transarterial chemoembolization.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2014
    Article
  18. Decision making in liver transplantation--limited application of the liver donor risk index.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2014
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sanjeev K AkkinaDepartment of Medicine, University of Illinois, Chicago, IL, USA.
Sumeet K Asrani
Yi Peng
Peter Stock
W Ray Kim
Ajay K Israni

Funding

Novel Biomarkers in Interstitial Fibrosis/Tubular Atrophy in Kidney TransplantsK23DK084121 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AKKINA, SANJEEV KUMAR · 2009 to 2013
$760k
NIDDK NIH HHS K23 DK084121NIDDK NIH HHS K23DK084121
6 · The paper itself

Abstract

Because of the shortage of deceased donor organs, transplant centers accept organs from marginal deceased donors, including older donors. Organ-specific donor risk indices have been developed to predict graft survival with various combinations of donor and recipient characteristics. Here we review the kidney donor risk index (KDRI) and the liver donor risk index (LDRI) and compare and contrast their strengths, limitations, and potential uses. The KDRI has a potential role in developing new kidney allocation algorithms. The LDRI allows a greater appreciation of the importance of donor factors, particularly for hepatitis C virus-positive recipients; as the donor risk index increases, the rates of allograft and patient survival among these recipients decrease disproportionately. The use of livers with high donor risk indices is associated with increased hospital costs that are independent of recipient risk factors, and the transplantation of livers with high donor risk indices into patients with Model for End-Stage Liver Disease scores < 15 is associated with lower allograft survival; the use of the LDRI has limited this practice. Significant regional variations in donor quality, as measured by the LDRI, remain in the United States. We also review other potential indices for liver transplantation, including donor-recipient matching and the retransplant donor risk index. Although substantial progress has been made in developing donor risk indices to objectively assess donor variables that affect transplant outcomes, continued efforts are warranted to improve these indices to enhance organ allocation policies and optimize allograft survival.

Indexed as

Donor SelectionModels, StatisticalAdolescentAdultAgedFemaleGraft SurvivalHealthcare DisparitiesHumansKidney TransplantationLiver TransplantationMaleMiddle AgedResidence CharacteristicsRisk AssessmentRisk Factors

Identifiers

PMID22287036
PMCPMC3332103

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.