ArticleApplied and environmental microbiology2012
Biology and genome sequence of Streptococcus mutans phage M102AD.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Phage therapy as an alternative strategy for oral bacterial infections: a systematic review.BMC oral health · 2025Pooled it
- Defense Systems and Prophage Detection in Streptococcus mutans Strains.Molecular oral microbiology · 2026Article
- CRISPR spacer profiling and prophage mining reveal diverse bacteriophages associated withJournal of oral microbiology · 2026Article
- Bacteriophage-mediated biofilm control: a novel targeted strategy for the management of dental caries.Frontiers in cellular and infection microbiology · 2026Review
- Recent perspectives on precision-targeting therapy against oral biofilm.Journal of oral microbiology · 2026Review
- Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance toMicrobiology (Reading, England) · 2025Article
- Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance tobioRxiv : the preprint server for biology · 2025Article
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- The applications of animal models in phage therapy: An update.Human vaccines & immunotherapeutics · 2023Review
- Isolation ofiScience · 2023Article
- Dental caries and their microbiomes in children: what do we do now?Journal of oral microbiology · 2023Review
- Investigating CRISPR spacer targets and their impact on genomic diversification ofFrontiers in genetics · 2022Article
- Determination of phage load and administration time in simulated occurrences of antibacterial treatments.Frontiers in medicine · 2022Article
- Phage TargetingAntibiotics (Basel, Switzerland) · 2021Article
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- Isolation and Characterization ofViruses · 2021Article
- Recombinant bacteriophage T4 Rnl1 impacts Streptococcus mutans biofilm formation.Journal of oral microbiology · 2020Article
- Characterization of a Type II-A CRISPR-Cas System inmSphere · 2020Article
- A mutation in the methionine aminopeptidase gene provides phage resistance in Streptococcus thermophilus.Scientific reports · 2019Article
- A Linear Plasmid-Like Prophage of Actinomyces odontolyticus Promotes Biofilm Assembly.Applied and environmental microbiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
M102AD is the new designation for a Streptococcus mutans phage described in 1993 as phage M102. This change was necessitated by the genome analysis of another S. mutans phage named M102, which revealed differences from the genome sequence reported here. Additional host range analyses confirmed that S. mutans phage M102AD infects only a few serotype c strains. Phage M102AD adsorbed very slowly to its host, and it cannot adsorb to serotype e and f strains of S. mutans. M102AD adsorption was blocked by c-specific antiserum. Phage M102AD also adsorbed equally well to heat-treated and trypsin-treated cells, suggesting carbohydrate receptors. Saliva and polysaccharide production did not inhibit plaque formation. The genome of this siphophage consisted of a linear, double-stranded, 30,664-bp DNA molecule, with a GC content of 39.6%. Analysis of the genome extremities indicated the presence of a 3'-overhang cos site that was 11 nucleotides long. Bioinformatic analyses identified 40 open reading frames, all in the same orientation. No lysogeny-related genes were found, indicating that phage M102AD is strictly virulent. No obvious virulence factor gene candidates were found. Twelve proteins were identified in the virion structure by mass spectrometry. Comparative genomic analysis revealed a close relationship between S. mutans phages M102AD and M102 as well as with Streptococcus thermophilus phages. This study also highlights the importance of conducting research with biological materials obtained from recognized microbial collections.
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