ArticleMycopathologia2012
Immune response against Sporothrix schenckii in TLR-4-deficient mice.
Article in Mycopathologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice.Frontiers in immunology · 2026Article
- Current Insights intoJournal of fungi (Basel, Switzerland) · 2025Article
- Differential Recognition of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2023Article
- Innate Immune Responses to Sporothrix schenckii: Recognition and Elimination.Mycopathologia · 2023Review
- Differential Recognition ofInfection and drug resistance · 2023Article
- Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2022Review
- Extracellular Vesicles From Sporothrix brasiliensis Yeast Cells Increases Fungicidal Activity in Macrophages.Mycopathologia · 2021Article
- Disruption of protein rhamnosylation affects theCell surface (Amsterdam, Netherlands) · 2021Article
- The Role of Macrophages in the Host's Defense againstPathogens (Basel, Switzerland) · 2021Review
- Complement-Mediated Differential Immune Response of Human Macrophages toFrontiers in immunology · 2021Article
- Skin Mast Cells Contribute toFrontiers in immunology · 2020Article
- Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii.Immunology · 2018Article
- Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis.PloS one · 2018Article
- The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.Immunology · 2017Article
- Article
- Molecular Components of the Sporothrix schenckii Complex that Induce Immune Response.Current microbiology · 2016Review
- Response of Cytokines and Hydrogen Peroxide to Sporothrix schenckii Exoantigen in Systemic Experimental Infection.Mycopathologia · 2016Article
- Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis.Journal of immunology research · 2016Article
- Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis.Mycopathologia · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages’ ability to recognize Sporothrix schenckii through specific receptors for some of the fungus’ cellular surface constituents. Further confirmation for macrophages’ pivotal role in fungal diseases came with the identification of toll-like receptors, and the subsequent numerous associations found between TLR-4 deficiency and host susceptibility to diverse fungal pathogens. Involvement of TLR-4 in immune response against sporotrichosis has been conducted to investigate how TLR-4 signaling could affect inflammatory response development through evaluation of H2O2 production and IL-1β, IL-6 and TGF-β release during the course of S. schenckii infection on TLR-4-deficient mice. The results showed that macrophages are largely dependent on TLR-4 for inflammatory activation and that in the absence of TLR-4 signaling, increased TGF-β release may be one of the contributing factors for the abrogated inflammatory activation of peritoneal exudate cells during mice sporotrichosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.