ReviewAsian journal of andrology2012
How to recognize late-onset hypogonadism in men with sexual dysfunction.
Review in Asian journal of andrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Testosterone supplementation and body composition: results from a meta-analysis of observational studies.Journal of endocrinological investigation · 2016Pooled it
- Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology.Journal of endocrinological investigation · 2015Pooled it
- Trial
- Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial.Journal of endocrinological investigation · 2017Trial
- Validation of the Turkish version of the ANDROTEST for detecting male hypogonadism in patients with sexual dysfunction.Sexual medicine · 2026Article
- Diagnostic Uncertainty in a Patient With Late-Onset Hypogonadism-Like Symptoms: A Case Report.Cureus · 2026Article
- Developing a persona-driven, mHealth-enabled care model for young men with hypogonadism: a methods-based approach to early risk stratification and prevention.Frontiers in reproductive health · 2025Article
- Hypogonadism and nonalcoholic fatty liver disease.Endocrine · 2024Review
- Correlation between visceral fat metabolism score and erectile dysfunction: a cross-sectional study from NHANES 2001-2004.Frontiers in endocrinology · 2023Article
- High incidence of sexual dysfunction and timed intercourse was found only in infertile males who with known impairment of sperm quality for a long period: evidence from a hospital-based cross-sectional study.Reproductive biology and endocrinology : RB&E · 2022Article
- The Role of Testosterone in the Elderly: What Do We Know?International journal of molecular sciences · 2022Review
- Increased risk of testosterone deficiency is associated with the systemic immune-inflammation index: a population-based cohort study.Frontiers in endocrinology · 2022Article
- Waist Circumference Is More Closely Associated with Hypogonadism than Is Hyperglycemia, Independent of BMI in Middle-Aged Men.Journal of diabetes research · 2021Article
- Metabolic Disorders and Male Hypogonadotropic Hypogonadism.Frontiers in endocrinology · 2019Review
- Long-term safety, health and mental status in men with vasectomy.Scientific reports · 2018Article
- Androgen Receptor CAG Repeat Length as a Risk Factor of Late-Onset Hypogonadism in a Korean Male Population.Sexual medicine · 2018Article
- Aging and sex hormones in males.Virulence · 2017Review
- The relationship between acquired premature ejaculation and metabolic syndrome: a prospective, comparative study.International journal of impotence research · 2017Article
- The inter-relational effect of metabolic syndrome and sexual dysfunction on hypogonadism in type II diabetic men.International journal of impotence research · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-onset hypogonadism (LOH) has been considered the most common form of male hypogonadism with a prevalence of approximately 1 in 100 men. Diagnosis of LOH should be made in symptomatic men with unequivocally low serum testosterone (T) levels. However, its clinical presentation is often insidious and difficult to recognize because it is characterized by nonspecific symptoms that make differential diagnosis with physiological ageing problematic. Sexual dysfunction is the most important determinant for medical consultation and the most specific symptom associated with low T. We therefore analysed a consecutive series of 1734 subjects who attended our unit for sexual dysfunction to investigate the associations between low T (different thresholds), sexual parameters, medical history data (delayed puberty, pituitary disease or cryptorchidism) and their physical exam results. Metabolic parameters, in particular waist circumference, display the greatest accuracy in detecting low T. We found that only the association of several symptoms and signs could significantly raise the clinical suspicion of low T. Structured inventories, which cluster together symptoms and signs of hypogonadism, can help clinicians suspect androgen deficiency. In particular, structured interviews, such as ANDROTEST, have been demonstrated to have a greater accuracy when compared to self reported questionnaires in detecting low T levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.