ArticleVirulence
Nitric oxide nanoparticles: pre-clinical utility as a therapeutic for intramuscular abscesses.
Article in Virulence. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Versatile nanomaterials used in combatting biofilm infections.Nanomedicine (London, England) · 2025Review
- Nitric Oxide in the Treatment of COVID-19: Nasal Sprays, Inhalants and Nanoparticles.Biochemistry research international · 2025Review
- Recent Strategies to Combat Biofilms Using Antimicrobial Agents and Therapeutic Approaches.Pathogens (Basel, Switzerland) · 2022Review
- Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound.Nanomaterials (Basel, Switzerland) · 2022Review
- Nitric Oxide-Releasing Nanoparticles Are Similar to Efinaconazole in Their Capacity to EradicateFrontiers in cellular and infection microbiology · 2021Article
- Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide.Frontiers in physiology · 2020Article
- Antibacterial and Cellular Response Toward a Gasotransmitter-Based Hybrid Wound Dressing.ACS biomaterials science & engineering · 2019Article
- Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance.International journal of molecular sciences · 2019Review
- Antibacterial 3D bone scaffolds for tissue engineering application.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Anti-Methicillin-ResistantFrontiers in pharmacology · 2019Review
- Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications.Advanced healthcare materials · 2018Review
- Liquid-infused nitric oxide-releasing (LINORel) silicone for decreased fouling, thrombosis, and infection of medical devices.Scientific reports · 2017Article
- Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications.ACS central science · 2017Review
- Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Review
- Duchenne Muscular Dystrophy: From Diagnosis to Therapy.Molecules (Basel, Switzerland) · 2015Review
- Nitric oxide therapy for dermatologic disease.Future science OA · 2015Review
- Nanoparticle delivery of antisense oligonucleotides and their application in the exon skipping strategy for Duchenne muscular dystrophy.Nucleic acid therapeutics · 2014Review
- Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond.FEMS microbiology reviews · 2013Review
- A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response.Nitric oxide : biology and chemistry · 2012Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a critical component of host defense against invading pathogens; however, its therapeutic utility is limited due to a lack of practical delivery systems. Recently, a NO-releasing nanoparticulate platform (NO-np) was shown to have in vitro broad-spectrum antimicrobial activity and in vivo pre-clinical efficacy in a dermal abscess model. To extend these findings, both topical (TP) and intralesional (IL) NO-np administration was evaluated in a MRSA intramuscular murine abscess model and compared with vancomycin. All treatment arms accelerated abscess clearance clinically, histologically, and by microbiological assays on both days 4 and 7 following infection. However, abscesses treated with NO-np via either route demonstrated a more substantial, statistically significant decrease in bacterial survival based on colony forming unit assays and histologically revealed less inflammatory cell infiltration and preserved muscular architecture. These data suggest that the NO-np may be an effective addition to our armament for deep soft tissue infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.