ArticleCancer causes & control : CCC2012
Body size and the risk of postmenopausal breast cancer subtypes in the California Teachers Study cohort.
Article in Cancer causes & control : CCC, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- How does weight gain since the age of 18 years affect breast cancer risk in later life? A meta-analysis.Breast cancer research : BCR · 2024Pooled it
- The relationship between central obesity and risk of breast cancer: a dose-response meta-analysis of 7,989,315 women.Frontiers in nutrition · 2023Pooled it
- Body mass index had different effects on premenopausal and postmenopausal breast cancer risks: a dose-response meta-analysis with 3,318,796 subjects from 31 cohort studies.BMC public health · 2017Pooled it
- BMI, reproductive factors, and breast cancer molecular subtypes: A case-control study and meta-analysis.Journal of epidemiology · 2017Pooled it
- Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.Journal of the National Cancer Institute · 2015Pooled it
- Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies.Scientific reports · 2014Pooled it
- The association between adiposity indices and the odds of breast cancer based on findings from a case control study.Scientific reports · 2025Article
- Effects of Endocrine Interventions Targeting ERα or PR on Breast Cancer Risk in the General Population and Carriers ofInternational journal of molecular sciences · 2024Review
- Body mass index and altered lipid profile as major risk markers for breast cancer progression: a cross-sectional study of postmenopausal women in Pakistan.BMC women's health · 2024Article
- Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer.Breast cancer research : BCR · 2023Article
- Genetic Associations with Smoking Relapse and Proportion of Follow-up in Smoking Relapse throughout Adulthood in Pre- and Postmenopausal Women.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Rat Mammary carcinoma susceptibility 3 (Mcs3) pleiotropy, socioenvironmental interaction, and comparative genomics with orthologous human 15q25.1-25.2.G3 (Bethesda, Md.) · 2023Article
- The Association of Predicted Resting Energy Expenditure with Risk of Breast Cancer among Postmenopausal Women in the Women's Health Initiative Cohort.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study.American journal of epidemiology · 2022Article
- Article
- Central Adiposity and Subsequent Risk of Breast Cancer by Menopause Status.Journal of the National Cancer Institute · 2021Article
- Article
- Crown-Like Structures in Breast Adipose Tissue: Early Evidence and Current Issues in Breast Cancer.Cancers · 2021Review
- Obesity and Androgen Receptor Signaling: Associations and Potential Crosstalk in Breast Cancer Cells.Cancers · 2021Review
- Molecular insights into the interplay between adiposity, breast cancer and bone metastasis.Clinical & experimental metastasis · 2021Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate how the association between body size and breast cancer risk varies by tumor receptor subtype, host factors, and other exposures among women in the California Teachers Study cohort.
methodsAmong 52,642 postmenopausal women, 2,321 developed invasive breast cancer with known estrogen- and progesterone-receptor status (1,652 ER+PR+, 338 ER+PR-, and 312 ER-PR-) between 1995 and 2007. In a subset of 35,529 with waist circumference data, 1,377 developed invasive breast cancer with known ERPR status (991 ER+PR+, 208 ER+PR-, 169 ER-PR-) between 1997 and 2007. Multivariate Cox regression was performed to estimate relative risks (RR) and 95% confidence intervals (CI).
resultsObesity, adult weight gain of ≥40 pounds, greater abdominal adiposity, and greater height increased the risk of ER+PR+ breast cancer. The increased risk associated with postmenopausal obesity was limited to those who did not use hormone therapy (HT) at cohort entry (RR = 1.37; 95% CI, 1.05-1.78 for BMI ≥ 30 vs. < 25 kg/m(2); p-interaction = 0.14) and those who were not overweight or obese at age 18 (p-interaction = 0.06). The increased risk associated with greater abdominal adiposity was limited to those who were not also overweight or obese (p-interaction = 0.01). Neither obesity, abdominal adiposity, nor height was associated with the risk of ER-PR- tumors.
conclusionsThe effects of body size on postmenopausal breast cancer risk differed by hormone receptor subtype, and among women with ER+PR+ tumors, by HT use and early adult body size.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.