ArticleNature chemical biology2012
Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development.
Article in Nature chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function.Angewandte Chemie (International ed. in English) · 2024Article
- PhotocleavableChemical reviews · 2023Review
- Article
- Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing.Chembiochem : a European journal of chemical biology · 2022Article
- The Development and Application of Opto-Chemical Tools in the Zebrafish.Molecules (Basel, Switzerland) · 2022Review
- Fli1Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Combinatorial control of gene function with wavelength-selective caged morpholinos.Methods in enzymology · 2019Article
- Article
- Illuminating developmental biology through photochemistry.Nature chemical biology · 2017Article
- Article
- Tbx16 regulates hox gene activation in mesodermal progenitor cells.Nature chemical biology · 2016Article
- A novel cold-sensitive mutant of ntla reveals temporal roles of brachyury in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Development of Photoactivated Fluorescent N-Hydroxyoxindoles and Their Application for Cell-Selective Imaging.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Caged oligonucleotides for studying biological systems.Journal of inorganic biochemistry · 2015Review
- Optochemical dissection of T-box gene-dependent medial floor plate development.ACS chemical biology · 2015Article
- Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing.ACS chemical biology · 2014Article
- Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.Angewandte Chemie (International ed. in English) · 2014Article
- Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach.Accounts of chemical research · 2014Article
- General method for regulating protein stability with light.ACS chemical biology · 2014Article
- Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development.The Journal of biological chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcription factors have diverse roles during embryonic development, combinatorially controlling cellular states in a spatially and temporally defined manner. Resolving the dynamic transcriptional profiles that underlie these patterning processes is essential for understanding embryogenesis at the molecular level. Here we show how temporal, tissue-specific changes in embryonic transcription factor function can be discerned by integrating caged morpholino oligonucleotides with photoactivatable fluorophores, fluorescence-activated cell sorting and microarray technologies. As a proof of principle, we have dynamically profiled No tail a (Ntla)-dependent genes at different stages of axial mesoderm development in zebrafish, discovering discrete sets of transcripts that are coincident with either notochord cell fate commitment or differentiation. Our studies reveal new regulators of notochord development and the sequential activation of distinct transcriptomes within a cell lineage by a single transcriptional factor and demonstrate how optically controlled chemical tools can dissect developmental processes with spatiotemporal precision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.