ArticleNeurobiology of aging2012
Behavioral decay in aging male C. elegans correlates with increased cell excitability.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan.GeroScience · 2026Article
- Automated analysis of C. elegans behavior by LabGym: an open-source, AI-powered platform.G3 (Bethesda, Md.) · 2026Article
- Automated analysis ofbioRxiv : the preprint server for biology · 2025Article
- A small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway.Aging cell · 2025Article
- Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans.GeroScience · 2024Review
- Male-specific behavioral and transcriptomic changes in agingiScience · 2024Article
- Unraveling the hierarchical structure of posture and muscle activity changes during mating ofPNAS nexus · 2024Article
- Decoding lifespan secrets: the role of the gonad inFrontiers in aging · 2024Review
- Evolutionarily conserved behavioral plasticity enables context-dependent mating in C. elegans.Current biology : CB · 2023Article
- Acrolein Promotes Aging and Oxidative Stress via the Stress Response Factor DAF-16/FOXO inFoods (Basel, Switzerland) · 2022Article
- Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically agingiScience · 2022Article
- WNT regulates programmed muscle remodeling through PLC-β and calcineurin inDevelopment (Cambridge, England) · 2020Article
- Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males.iScience · 2020Article
- Stress-Induced Neuron Remodeling Reveals Differential Interplay Between Neurexin and Environmental Factors inGenetics · 2019Article
- Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism.PLoS biology · 2019Article
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- Sexual Dimorphism and Sex Differences inGenetics · 2018Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Deteriorative changes in behavioral functions are natural processes that accompany aging. In advanced aged C. elegans nematodes, gross decline in general behaviors, such as locomotion and feeding, is correlated with degeneration of muscle structure and contractile function. In this study, we characterized the age-related changes in C. elegans male mating behavior to determine possible causes that ultimately lead to age-related muscle frailty. Unlike the kinetics of general behavioral decline, we found that mating behavior deteriorates early in adulthood, with no obvious muscle fiber disorganization or sperm dysfunction. Through direct mating behavior observations, Ca(2+) imaging, and pharmacological tests, we found that the muscular components used for mating become more excitable as the males age. Interestingly, manipulating either the expression of acetylcholine receptor (AChR) genes or dietary-mediated ether-a-go-go family K(+) channel function can reduce the muscle excitability of older males and concurrently improve mating behavior, suggesting a correlation between these biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.