ArticleMolecular cell2012
The WTX tumor suppressor enhances p53 acetylation by CBP/p300.
Article in Molecular cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 74 citations in OpenAlex.
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- Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells.Cell cycle (Georgetown, Tex.) · 2021Article
- Mir-20a-5p induced WTX deficiency promotes gastric cancer progressions through regulating PI3K/AKT signaling pathway.Journal of experimental & clinical cancer research : CR · 2020Article
- Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Knockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression.Cancers · 2020Article
- Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice.American journal of translational research · 2020Article
- Identification of p53 Activators in a Human Microarray Compendium.Chemical research in toxicology · 2019Article
- A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer CellsInternational journal of biological sciences · 2019Article
- Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer.Oncogenesis · 2018Article
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- c-Fos-dependent miR-22 targets MDC1 and regulates DNA repair in terminally differentiated cells.Oncotarget · 2017Article
- CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.Molecular oncology · 2016Article
- Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes.The Journal of pathology · 2016Article
- The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.The Journal of biological chemistry · 2015Article
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4 authors at 2 institutions in 1 country.
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Abstract
WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in β-catenin turnover, but its effect on nuclear proteins is unknown. We report an interaction between WTX and p53, derived from the unexpected observation of WTX, p53, and E1B 55K colocalization within the characteristic cytoplasmic body of adenovirus-transformed kidney cells. In other cells without adenovirus expression, the C-terminal domain of WTX binds to the DNA-binding domain of p53, enhances its binding to CBP, and increases CBP/p300-mediated acetylation of p53 at Lys 373/382. WTX knockdown accelerates CBP/p300 protein turnover and attenuates this modification of p53. In p53-reconstitution experiments, cell-cycle arrest, apoptosis, and p53 target-gene expression are suppressed by depletion of WTX. Together, these results suggest that WTX modulates p53 function, in part through regulation of its activator CBP/p300.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.